Insulin detemir treatment in diabetic cats in a practice setting

Abstract

Insulin detemir is a long-acting insulin analogue and may represent a valuable treatment option for diabetic cats. So far, only one study addressing detemir treatment of diabetic cats has been published, and this was based on an intensive blood glucose monitoring protocol. The aim of the current, retrospective study was to evaluate the effect of detemir therapy in diabetic cats in a general clinical setting. Fourteen diabetic cats with a follow-up period of at least 3 months were included. Data were collected from medical records at the University Hospital for Companion Animals, University of Copenhagen, Denmark. Thirteen of 14 cats achieved moderate or excellent control of clinical symptoms within the initial 3 months of detemir therapy, including five cats previously treated unsuccessfully with other types of insulin. Clinical improvements were noted after 1 month of therapy and continued over time. Three cats achieved remission within the initial 3 months and none experienced a diabetic relapse during the study period. One cat achieved remission after 13 months of therapy. Improvements in clinical symptoms were markedly better than indicated by blood glucose and serum fructosamine concentrations. The safety of detemir was very high, with only two reported episodes of clinical hypoglycaemia, neither of which required veterinary attention. Based on these results detemir can be recommended for the treatment of diabetic cats, including cats previously treated unsuccessfully with other types of insulin.

Figure 1

Mean serum fructosamine concentration in nine diabetic cats following initiation of detemir treatment. Time 0 is initiation of treatment, time 1 is 25–60 days and time 2 is 61–105 days after the initiation of treatment with detemir. P <0.05 between time 0 and 1. P = 0.03 between time 0 and 2

Figure 2

Mean preinsulin blood glucose (BG) concentration during a 12 h BG curve in nine diabetic cats following initiation of detemir treatment. Time 1 is 25–60 days and time 2 is 61–105 days after the initiation of treatment with detemir. P = 0.30 between time 1 and 2

Figure 3

Mean nadir blood glucose (BG) concentration during a 12 h BG curve in 10 diabetic cats following initiation of detemir treatment. Time 1 is 25–60 days and time 2 is 61–105 days after the initiation of treatment with detemir. P = 0.32 between time 1 and 2