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Review
. 2014 Aug;45(8):2527-31.
doi: 10.1161/STROKEAHA.114.002879. Epub 2014 Jun 17.

Reprogramming the response to stroke by preconditioning

Susan L Stevens  1 , Keri B Vartanian  1 , Mary P Stenzel-Poore  2
Affiliations
Review

Reprogramming the response to stroke by preconditioning

Susan L Stevens et al. Stroke. 2014 Aug.
No abstract available

Keywords: ischemia; ischemic preconditioning.

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Figures

Figure 1
Figure 1. Model of the phases of preconditioning induced reprogramming
Preconditioning engages endogenous mechanisms of protection that are developed through three phases of molecular alterations. The Priming phase initiates the response to the preconditioning stimuli. Induction of TNF in the brain may be a key component of the priming phase. The subsequent Refractive phase defines the period in which the response to an ischemic challenge is reprogrammed. Potential mediators of this phase are miRNA, epigenetic factors, and autophagy related changes in metabolism. The reprogrammed response to the injury results in the Neuroprotective phase, through sustaining cellular homeostasis, suppression of cellular infiltration in response to ischemia, and induction of IRF-mediated gene transcription.
See this image and copyright information in PMC

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