Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Dec;13(4):955-61.
doi: 10.4314/ahs.v13i4.14.

Seroprevalence of HBV and HIV co-infection in children and outcomes following highly active antiretroviral therapy (HAART) in Uyo, South-South Nigeria

E E Ikpeme  1 , O M Etukudo  1 , U E Ekrikpo  2
Affiliations

Seroprevalence of HBV and HIV co-infection in children and outcomes following highly active antiretroviral therapy (HAART) in Uyo, South-South Nigeria

E E Ikpeme et al. Afr Health Sci. 2013 Dec.

Abstract

Background: Human Immunodeficiency Virus/Hepatitis B Virus (HIV/HBV) co-infection in Nigerian children has emerged as a major concern with the advent of HAART. Its impact on the immune system and liver has not been extensively studied in children.

Objectives: To determine the prevalence of HBV seropositivity among HIV positive children on HAART and its effect on immune response and liver enzymes.

Methods: All consecutive HIV positive children aged two months to seventeen years on HAART constituted the study population. Age and gender; CD4+ count, ALT, creatinine and HBsAg were tested and documented at enrolment and 12months.

Results: One hundred and seventy one patients were seen over this period. Seventy-two (43.4%) were males while 94 (56.6%) were females giving a male: female ratio of 1:1.3. The mean age of the patients was 63±43.4 months. Prevalence of HIV/HBV co-infection was 6.02% (95% CI 2.4-9.7). There was no significant effect of HBV status on elevation of ALT levels with 12 months of HAART. Co-infected patients had an odds ratio of achieving immune response of 0.14 (95% CI 0.02-0.79).

Conclusion: HIV/HBV co-infection rates in our children are comparable to other localities. ALT levels do not worsen with HAART and immune response of the co-infected children on HAART is lower.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Graph box showing CD4 count by HBV status
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. National Agency for the Control of AIDS, author. United Nations General assembly Special Session (UNGASS) Country Progress Report Nigeria. [20 January 2012]. Reportin Period January 2008– December2009 http://www.unaids.org/fr/dataanalysis/monitoringcountryprogress/2010prog....
    1. United Nations Children's Fund, author. State of the World's Children. New York: 2009.
    1. Federal Ministry of Health, Nigeria, author. National Guidelines for Paediatric HIV and AIDS treatment and care. Abuja, Nigeria: 2007.
    1. Joint United Nations Programme on HIV/AIDS (UNAIDS) and World Health Organization (WHO) AIDS epidemic update: December 2006. [25 January 2012]. Available at: http://www.unaids.org/en/HIVdata 2007 Epi Update/default.asp.
    1. Konopricki D, Mocroft A, deWit S. Hepatitis B and HIV : prevalence, AIDS progression, response to HAART and increased mortality in the EuroSIDA cohort. AIDS. 2005;19:593–601. - PubMed

MeSH terms