NK cells and virus-related cancers
- PMID: 24941377
- PMCID: PMC4196716
- DOI: 10.1615/critrevoncog.2014010866
NK cells and virus-related cancers
Abstract
Natural killer (NK) cells become activated during viral infections and can play roles in such infections by attacking virus-infected cells or by regulating adaptive immune responses. Experimental models suggest that NK cells may also have the capacity to restrain virus-induced cancers. Here, we discuss the seven viruses linked to human cancers and the evidence of NK cell involvement in these systems.
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References
-
- Raulet DH. Roles of the NKG2D immuno-receptor and its ligands. Nat Rev Immunol. 2003;3:781–90. - PubMed
-
- Lee SH, Girard S, Macina D, Busà M, Zafer A, Belouchi A, Gros P, Vidal SM. Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nat Genet. 2001;28:42–5. - PubMed
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