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Review
. 2014 May;10(6):949-56.
doi: 10.2217/fon.14.56.

Elotuzumab for the treatment of multiple myeloma

Philippe Moreau  1 , Cyrille Touzeau
Affiliations
Review

Elotuzumab for the treatment of multiple myeloma

Philippe Moreau et al. Future Oncol. 2014 May.

Abstract

New agents are awaited for the treatment of multiple myeloma and research is ongoing for the development of monoclonal antibodies (MoAbs) targeting the tumor cells. One of the most promising MoAb is elotuzumab, the only humanized IgG1 MoAb specifically targeting CS1 (SLAMF7), a cell surface glycoprotein that is highly expressed in plasma cells. Preclinical and clinical data on elotuzumab will be presented in this article.

Keywords: CS1; elotuzumab; lenalidomide; monoclonal antibody; multiple myeloma.

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