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Comment
. 2014 Jul;96(1):15-7.
doi: 10.1038/clpt.2014.44.

Patients benefit from genetics-guided coumarin anticoagulant therapy

A H Maitland-van der Zee  1 , A K Daly  2 , F Kamali  2 , V G Manolopoulous, T I Verhoef  1 , M Wadelius  3 , A de Boer  1 , M Pirmohamed  4 ; EU-PACT Study Group
Affiliations
Comment

Patients benefit from genetics-guided coumarin anticoagulant therapy

A H Maitland-van der Zee et al. Clin Pharmacol Ther. 2014 Jul.

Erratum in

  • Clin Pharmacol Ther. 2014 Sep;96(3):397. Manolopoulos, V G [corrected to Manolopoulous, V G]

Abstract

Observational studies have overwhelmingly shown that variants in the genes CYP2C9 and VKORC1 are significant determinants of individual dose of coumarin anticoagulants needed to maintain a therapeutic international normalized ratio (INR).(1) Until recently, however, few randomized clinical trials had been performed relating to the use of genetic data to predict dosing. Three sucsh clinical trials have now reported their findings.

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Comment on

  • Long-term anticoagulant effects of the CYP2C9 and VKORC1 genotypes in acenocoumarol users.
    Verhoef TI, Redekop WK, Buikema MM, Schalekamp T, Van Der Meer FJ, Le Cessie S, Wessels JA, Van Schie RM, De Boer A, Teichert M, Visser LE, Maitland-Van Der Zee AH; EU-PACT Group. Verhoef TI, et al. J Thromb Haemost. 2012 Apr;10(4):606-14. doi: 10.1111/j.1538-7836.2012.04633.x. J Thromb Haemost. 2012. PMID: 22252093
  • A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon.
    Verhoef TI, Ragia G, de Boer A, Barallon R, Kolovou G, Kolovou V, Konstantinides S, Le Cessie S, Maltezos E, van der Meer FJ, Redekop WK, Remkes M, Rosendaal FR, van Schie RM, Tavridou A, Tziakas D, Wadelius M, Manolopoulos VG, Maitland-van der Zee AH; EU-PACT Group. Verhoef TI, et al. N Engl J Med. 2013 Dec 12;369(24):2304-12. doi: 10.1056/NEJMoa1311388. Epub 2013 Nov 19. N Engl J Med. 2013. PMID: 24251360 Clinical Trial.
  • A randomized trial of genotype-guided dosing of warfarin.
    Pirmohamed M, Burnside G, Eriksson N, Jorgensen AL, Toh CH, Nicholson T, Kesteven P, Christersson C, Wahlström B, Stafberg C, Zhang JE, Leathart JB, Kohnke H, Maitland-van der Zee AH, Williamson PR, Daly AK, Avery P, Kamali F, Wadelius M; EU-PACT Group. Pirmohamed M, et al. N Engl J Med. 2013 Dec 12;369(24):2294-303. doi: 10.1056/NEJMoa1311386. Epub 2013 Nov 19. N Engl J Med. 2013. PMID: 24251363 Clinical Trial.

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