Tau propagation, different tau phenotypes, and prion-like properties of tau
- PMID: 24945760
- DOI: 10.1016/j.neuron.2014.06.004
Tau propagation, different tau phenotypes, and prion-like properties of tau
Abstract
Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Distinct tau prion strains propagate in cells and mice and define different tauopathies.Neuron. 2014 Jun 18;82(6):1271-88. doi: 10.1016/j.neuron.2014.04.047. Epub 2014 May 22. Neuron. 2014. PMID: 24857020 Free PMC article.
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