Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Apr;86(7):2478-82.
doi: 10.1073/pnas.86.7.2478.

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor

D R Rosen  1 , L Martin-Morris, L Q Luo, K White
Affiliations

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor

D R Rosen et al. Proc Natl Acad Sci U S A. 1989 Apr.

Abstract

We have isolated genomic and cDNA clones for a Drosophila gene resembling the human beta-amyloid precursor protein (APP). This gene produces a nervous system-enriched 6.5-kilobase transcript. Sequencing of cDNAs derived from the 6.5-kilobase transcript predicts an 886-amino acid polypeptide. This polypeptide contains a putative transmembrane domain and exhibits strong sequence similarity to cytoplasmic and extracellular regions of the human beta-amyloid precursor protein. There is a high probability that this Drosophila gene corresponds to the essential Drosophila locus vnd, a gene required for embryonic nervous system development.

PubMed Disclaimer

References

    1. Science. 1987 Jul 3;237(4810):77-80 - PubMed
    1. Nucleic Acids Res. 1987 Feb 25;15(4):1353-61 - PubMed
    1. Nature. 1988 Feb 11;331(6156):530-2 - PubMed
    1. Science. 1987 Feb 20;235(4791):880-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12 - PubMed

Publication types

Associated data