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Comment
. 2014 Sep;24(9):1021-2.
doi: 10.1038/cr.2014.80. Epub 2014 Jun 20.

Pain-induced skin autoimmunity

Francesca Odoardi  1 , Winfried Neuhuber  2 , Alexander Flügel  1
Affiliations
Comment

Pain-induced skin autoimmunity

Francesca Odoardi et al. Cell Res. 2014 Sep.

Abstract

A recent paper published in Nature reports sensory nerve fibers in the skin that give local immune cells important instructions for the organization of an immune response; in this particular case the cooperation between the nervous and immune systems had disastrous consequences, namely an auto-destruction of the skin.

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Figures

Figure 1
Figure 1
Schematic drawing of intact skin. Afferent nerve (red); efferent nerve (blue). Magnification of the chain of events that drives the formation of the psoriatic lesions upon activation of the TRPV1+ and Nav1.8+ sensory neurons.
See this image and copyright information in PMC

Comment on

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