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Editorial
. 2014 Nov;13(11):1275-8.
doi: 10.1586/14760584.2014.932693. Epub 2014 Jun 20.

The importance of B cell CD1d expression for humoral immunity

Mark L Lang  1
Affiliations
Editorial

The importance of B cell CD1d expression for humoral immunity

Mark L Lang. Expert Rev Vaccines. 2014 Nov.

Abstract

It was reported over a decade previously that CD1d-restricted Natural Killer T (NKT) cells could interact with CD1d-expressing B cells and facilitate antibody secretion. Since then, several studies have observed that NKT cells can provide B-cell help for production of antibody against model and pathogen-derived glycolipids, carbohydrates and proteins. In regard to T cell-dependent protein antigens, it is still not entirely clear to what extent cognate interactions between CD1d-expressing B cells and NKT cells contribute to initial and long-lived B-cell responses that are characteristic of such antigens. In this editorial, we review evidence that NKT cells provide CD1d-dependent cognate and non-cognate forms of B-cell help following immunization with protein antigen. Elucidating these mechanisms will be important for harnessing NKT cells during vaccination.

Keywords: B lymphocyte; CD1d; NKT cell; antibody; cognate interactions.

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References

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