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. 2014 May 19;45(1):243-7.
doi: 10.1590/s1517-83822014000100035. eCollection 2014.

Paracoccidioidomycosis in southern Rio Grande do Sul: a retrospective study of histopathologically diagnosed cases

Silvana Pereira de Souza  1 , Valéria Magalhães Jorge  2 , Melissa Orzechowski Xavier  3
Affiliations

Paracoccidioidomycosis in southern Rio Grande do Sul: a retrospective study of histopathologically diagnosed cases

Silvana Pereira de Souza et al. Braz J Microbiol. .

Abstract

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the fungus Paracoccidioides brasiliensis and is endemic to Brazil. The aim of this study was to perform a retrospective analysis of the PCM cases in the countryside south of Rio Grande do Sul, Brazil. The files from four histopathology laboratories located in the city of Pelotas were obtained, and all of the epidemiological and clinical data from the PCM diagnosed cases were collected for analysis. A total of 123 PCM cases diagnosed between 1966 and 2009 were selected. Of these patients, 104 (84.5%) were male, and 17 were female. The patients ranged from 02 to 92 years of age. Fifty-two cases (41.9%) were obtained from the oral pathology laboratory, and the remaining 71 cases (58.1%) were obtained from the three general pathology laboratories. Of all of the patients studied, 65.2% lived in rural zones and worked in agriculture or other related fields. Data on the evolution of this disease was available for 43 cases, and the time frame ranged from 20 to 2920 days (mean = 572.3 days). An accurate diagnosis performed in less than 30 days only occurred in 21% of the cases. PCM is endemic to the countryside of Rio Grande do Sul. Therefore, it is recommended that PCM be included as a differential diagnosis, mainly for individuals between 30 and 60 years of age, living in rural zones and who have respiratory signs and associated-oropharyngeal lesions.

Keywords: Paracoccidioides brasiliensis; epidemiology; systemic mycosis.

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Figures

Figure 1
Figure 1
Histological section of a lesion in the oral mucosa stained with Gomori-Grocott. Black dots indicate the presence of multiple budding blastoconidia characteristic of P. brasiliensis (400x).
Figure 2
Figure 2
Number of PCM cases diagnosed in pathology labs in Pelotas, RS, Brazil during the four decades included in the study.
Figure 3
Figure 3
Cities of origin for the patients with paracoccidioidomycosis diagnosed in pathology labs in the city of Pelotas, RS, Brazil (CA: Canguçu; P: Pelotas; SBV: Santana da Boa Vista; SLS: São Lourenço do Sul; PI: Piratini; C: Cristal; B: Bagé; J: Jaguarão; PO: Pedro Osório; RG: Rio Grande; SJN: São José do Norte).
See this image and copyright information in PMC

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