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. 2014 May;30(3):634-7.
doi: 10.12669/pjms.303.4558.

Vascular Endothelial Growth Factor expression in peripheral blood of patients with pregnancy induced hypertension syndrome and its clinical significance

Yanfang Ren  1 , Huiling Wang  2 , Haixia Qin  3 , Jun Yang  4 , Yuhong Wang  5 , Shan Jiang  6 , Ying Pan  7
Affiliations

Vascular Endothelial Growth Factor expression in peripheral blood of patients with pregnancy induced hypertension syndrome and its clinical significance

Yanfang Ren et al. Pak J Med Sci. 2014 May.

Abstract

Objective: This study was conducted was to detect vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) syndrome and to investigate VEGF correlation with PIH occurrence.

Methods: Double-antibody enzyme-linked immunosorbent assay and fluorescent quantitative polymerase chain reaction were used to detect VEGF levels in the peripheral blood of non-pregnant women (normal group, 30 cases), normal pregnant women (pregnancy group, 30 cases) and PIH patients (PIH group, 30 cases).

Results: VEGF level in the pregnancy group was significantly higher than in the normal group, and the difference between these two groups was significant (P < 0.001). In the pregnancy group, VEGF reached the maximum level at the metaphase stage of pregnancy and started to decrease at advanced pregnancy. VEGF level in the PIH group was significantly lower than in the pregnancy group at advanced pregnancy (P < 0.01), and VEGF level significantly and gradually decreased with PIH aggravation (P < 0.05).

Conclusions: The significant decrease of VEGF level after pregnancy was possibly an important factor of PIH pathogenesis.

Keywords: Cardiovascular; Hypertension; Pregnancy complications; Vascular endothelial growth factor.

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References

    1. Mohan SK, Venkataramana G. Status of lipid Peroxidation, Glutathione, Ascorbic acid, Vitamin E & Antioxidant Enzymes in patients with pregnancy--induced hypertension. Indian J Physiol Pharmacol. 2007;51(3):284–288. - PubMed
    1. Lao-Nario BT. Nursing care of patients with pregnancy-induced Hypertension (continuing education credit) Philipp J Nurs. 1988;58(4):15–25. - PubMed
    1. Roach VJ, Hin LY, Tam WH, Ng KB, Rogers MS. The incidence of pregnancy-induced Hypertension among patients with carbohydrate intolerance. Hypertens Pregnancy. 2000;19(2):183–189. http://dx.doi.org/10.1081/PRG-100100134. - DOI - PubMed
    1. Kilian O, Alt V, Heiss C, Jonuleit T, Dingeldein E, Flesch I. New blood vessel formation & expression of VEGF receptors after implantation of platelet growth factor-enriched Biodegradable Nanocrystalline Hydroxyapatite. Growth Factors. 2005;23(2):125–133. http://dx.doi.org/10.1080/08977190500126306. - DOI - PubMed
    1. Liu Z, Kobayashi K, van Dinther M, van Heiningen SH, Valdimarsdottir G, van Laar T. VEGF & Inhibitors of TGFbeta type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha5-integrin expression. J Cell Sci. 2009;122(Pt 18):3294–3302. http://dx.doi.org/10.1242/jcs.048942. - DOI - PubMed

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