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Review
. 2014:2014:682717.
doi: 10.1155/2014/682717. Epub 2014 May 8.

Comparison of Two Old Phytochemicals versus Two Newly Researched Plant-Derived Compounds: Potential for Brain and Other Relevant Ailments

Chun-Mei Wang  1 , Willmann Liang  1 , D T Yew  2
Affiliations
Review

Comparison of Two Old Phytochemicals versus Two Newly Researched Plant-Derived Compounds: Potential for Brain and Other Relevant Ailments

Chun-Mei Wang et al. Evid Based Complement Alternat Med. 2014.

Abstract

Among hundreds of formulae of Chinese herbal prescriptions and recently extracted active components from the herbs, some of which had demonstrated their functions on nervous system. For the last decade or more, Gingko biloba and Polygala tenuifolia were widely studied for their beneficial effects against damage to the brain. Two compounds extracted from Apium graveolens and Rhizoma coptidis, butylphthalide and berberine, respectively, received much attention recently as potential neuroprotective agents. In this review, the two traditionally used herbs and the two relatively new compounds will be discussed with regard to their potential advantages in alleviating brain and other relevant ailments.

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Figures

Figure 1
Figure 1
Leaf of Ginkgo biloba and chemical structure of some of the important constituents of EGb 761 [6].
Figure 2
Figure 2
The picture of Polygala tenuifolia and the structure of its two components, DISS and TEA [20].
Figure 3
Figure 3
The pictures of Apium graveolens and its seeds and the structure of NBP [37].
Figure 4
Figure 4
The picture of Rhizoma coptidis and the structure of berberine [53].
See this image and copyright information in PMC

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References

    1. Shi C, Yao Z, Xu J, Yew DT. Effects of Gingko Extract (EGb761) on oxidative damage under different conditions of serum supply. Journal of Bioenergetics and Biomembranes. 2009;41(1):61–69. - PubMed
    1. Shi C, Zhao L, Zhu B, et al. Dosage effects of EGb761 on hydrogen peroxide-induced cell death in SH-SY5Y cells. Chemico-Biological Interactions. 2009;180(3):389–397. - PubMed
    1. Shi C, Xiao S, Liu J, et al. Ginkgo biloba extract EGb761 protects against aging-associated mitochondrial dysfunction in platelets and hippocampi of SAMP8 mice. Platelets. 2010;21(5):373–379. - PubMed
    1. Shi C, Fang L, Yew DT, Yao Z, Xu J. Ginkgo biloba extract EGb761 protects against mitochondrial dysfunction in platelets and hippocampi in ovariectomized rats. Platelets. 2010;21(1):53–59. - PubMed
    1. Chandrasekaran K, Mehrabian Z, Spinnewyn B, Chinopoulos C, Drieu K, Fiskum G. Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death. Pharmacopsychiatry. 2003;36(1):S89–S94. - PubMed

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