Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:2014:182303.
doi: 10.1155/2014/182303. Epub 2014 May 14.

The roles of biomarkers of oxidative stress and antioxidant in Alzheimer's disease: a systematic review

Affiliations

The roles of biomarkers of oxidative stress and antioxidant in Alzheimer's disease: a systematic review

Ya-Ting Chang et al. Biomed Res Int. 2014.

Abstract

Purpose: Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies.

Methods: PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD.

Results and conclusion: Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Oxidative stress in Alzheimer's dementia. APP: amyloid precursor protein; BACE: beta-secretase; ROS: reactive oxygen species; RNS: reactive nitrogen species; Aβ: amyloid β.

References

    1. Weiner MW, Veitch DP, Aisen PS, et al. The Alzheimer’s disease neuroimaging initiative: a review of papers published since its inception. Alzheimer’s and Dementia. 2012;8(1, supplement):S1–S68. - PMC - PubMed
    1. Hardy JA, Higgins GA. Alzheimer’s disease: the amyloid cascade hypothesis. Science. 1992;256(5054):184–185. - PubMed
    1. Smith MA, Rottkamp CA, Nunomura A, Raina AK, Perry G. Oxidative stress in Alzheimer's disease. Biochimica et Biophysica Acta. 2000;1502(1):139–144. - PubMed
    1. Migliore L, Fontana I, Trippi F, et al. Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients. Neurobiology of Aging. 2005;26(5):567–573. - PubMed
    1. Casado Á, Encarnación López-Fernández M, Concepción Casado M, De La Torre R. Lipid peroxidation and antioxidant enzyme activities in vascular and alzheimer dementias. Neurochemical Research. 2008;33(3):450–458. - PubMed

Publication types