Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:2014:581985.
doi: 10.1155/2014/581985. Epub 2014 May 15.

Antimicrobial activity of coronarin D and its synergistic potential with antibiotics

Nanthawan Reuk-ngam  1 , Nitirat Chimnoi  2 , Nisachon Khunnawutmanotham  1 , Supanna Techasakul  3
Affiliations

Antimicrobial activity of coronarin D and its synergistic potential with antibiotics

Nanthawan Reuk-ngam et al. Biomed Res Int. 2014.

Abstract

Coronarin D is a labdane-type diterpene from the rhizomes of Hedychium coronarium. In the view of our ongoing effort to explore its novel biological activity, antimicrobial activity study of coronarin D was performed. The results showed that coronarin D was active against tested Gram-positive bacteria, inactive for tested Gram-negative bacteria, and weakly active against tested fungi. The antibacterial effect of the combination of coronarin D with nine classical antibiotics against four Gram-positive bacteria was also evaluated. The fractional inhibitory concentration indices (FICI) of coronarin D-antibiotics combinations, calculated from the checkerboard assay, were used as synergism indicator. Out of 36 combinations, 47% showed total synergism, 33% had partial synergistic interaction, 17% showed no effect, and 3% showed antagonism. By combination with coronarin D at concentration of 0.25 minimal inhibitory concentration (MIC), the activities of antibiotics were boosted to 4- to 128-fold. These finding suggested an attractive approach to combat the infectious diseases by using coronarin D-antibiotic drug combination.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Structure of coronarin D (1).
Figure 2
Figure 2
Structures of coronarin D acetate (2), kaurenoic acid (3), (+)-totarol (4), abietic acid (5), (E)-labda-8(17),12-diene-15,16-dial (6), and (E)-8β,17-epoxylabd-12-ene-15,16-dial (7).
See this image and copyright information in PMC

References

    1. Jamison DT, Breman JG, Measham AR, et al. Disease Control Priorities in Developing Countries. Washington, DC, USA: World Bank; 2006. - PubMed
    1. Leoung GS, Mills J. Opportunistic Infections in Patients with the Acquired Immunodeficiency Syndrome. New York, NY, USA: Marcel Dekker; 1989.
    1. Inweregbu K, Dave J, Pittard A. Nosocomial infections. Continuing Education in Anaesthesia, Critical Care and Pain. 2005;5(1):14–17.
    1. 2013, http://www.cdc.gov/hai/organisms/pseudomonas.html.
    1. Mack D, Davies AP, Harris LG, Rohde H, Horstkotte MA, Knobloch JK-M. Microbial interactions in Staphylococcus epidermidis biofilms. Analytical and Bioanalytical Chemistry. 2007;387(2):399–408. - PubMed

MeSH terms

LinkOut - more resources