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Randomized Controlled Trial
. 2014 Jun 19;6(6):2348-59.
doi: 10.3390/nu6062348.

Dietary supplementation with a superoxide dismutase-melon concentrate reduces stress, physical and mental fatigue in healthy people: a randomised, double-blind, placebo-controlled trial

Julie Carillon  1 , Claire Notin  2 , Karine Schmitt  3 , Guy Simoneau  4 , Dominique Lacan  5
Affiliations
Randomized Controlled Trial

Dietary supplementation with a superoxide dismutase-melon concentrate reduces stress, physical and mental fatigue in healthy people: a randomised, double-blind, placebo-controlled trial

Julie Carillon et al. Nutrients. .

Abstract

Background: We aimed to investigate effects of superoxide dismutase (SOD)-melon concentrate supplementation on psychological stress, physical and mental fatigue in healthy people.

Methods: A randomized, double-blind, placebo-controlled trial was performed on 61 people divided in two groups: active supplement (n = 32) and placebo (n = 29) for 12 weeks. Volunteers were given one small hard capsule per day. One capsule contained 10 mg of SOD-melon concentrate (140 U of SOD) and starch for the active supplement and starch only for the placebo. Stress and fatigue were evaluated using four psychometric scales: PSS-14; SF-36; Stroop tests and Prevost scale.

Results: The supplementation with SOD-melon concentrate significantly decreased perceived stress, compared to placebo. Moreover, quality of life was improved and physical and mental fatigue were reduced with SOD-melon concentrate supplementation.

Conclusion: SOD-melon concentrate supplementation appears to be an effective and natural way to reduce stress and fatigue.

Trial registration: trial approved by the ethical committee of Poitiers (France), and the ClinicalTrials.gov Identifier is NCT01767922.

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Figures

Figure 1
Figure 1
Scores of PSS-14 scale (Mean ± SEM) before, between and after supplementation. Transverse comparison between groups are not significantly different (NS) for D0, but significantly different (* p < 0.05) for D28 and D84.
Figure 2
Figure 2
Scores of SF 36 scale (Mean ± SEM) before, between and after supplementation. Transverse comparison between groups are not significantly different (NS) for D0 and D28, but significantly different (* p < 0.05) for D84.
Figure 3
Figure 3
Scores of Stroop scale (Mean ± SEM) before, between and after supplementation. Transverse comparison between groups are not significantly different (NS) for D0, but significantly different (* p < 0.05; *** p < 0.001) for D28 and D84.
Figure 4
Figure 4
Scores of Prevost scale (Mean ± SEM) before, between and after supplementation. Transverse comparison between groups are not significantly different (NS) for D0 and D28, but significantly different (* p < 0.05) for D84.
See this image and copyright information in PMC

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