AHR: making the keratinocytes thick skinned
- PMID: 24950209
- DOI: 10.1016/j.immuni.2014.06.001
AHR: making the keratinocytes thick skinned
Abstract
Dysregulated signals from the external environment and/or the internal milieu of the skin can lead to pathological conditions such as psoriasis. Di Meglio et al. (2014) show that the environment-responsive transcription factor AhR acts in keratinocytes to suppress psoriatic lesions.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions.Immunity. 2014 Jun 19;40(6):989-1001. doi: 10.1016/j.immuni.2014.04.019. Epub 2014 Jun 5. Immunity. 2014. PMID: 24909886 Free PMC article.
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