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Editorial
. 2014 Jul;34(7):1333-5.
doi: 10.1161/ATVBAHA.114.303637.

Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease

Claudia Goettsch  1 , Hiroshi Iwata  1 , Elena Aikawa  2
Affiliations
Editorial

Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease

Claudia Goettsch et al. Arterioscler Thromb Vasc Biol. 2014 Jul.
No abstract available

Keywords: atherosclerosis; bone; calcification; cardiovascular; inflammation.

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Figures

Figure 1
Figure 1. PTH as a novel mediator of bone-vascular-renal interaction
Cardiovascular disorders include but not limited to valvular and vascular calcification, atherosclerosis (inflammation) and hypertension.
Figure 2
Figure 2. Hypothetical signaling pathways of PTH receptor in cardiovascular disorders based on previously published reports
Solid arrows: previously reported pathways; dotted arrows: postulated but unknown pathways; ECs: endothelial cells; VSMCs: vascular smooth muscle cells; PTHrP: PTH-related peptide; Ox PTH: oxidized PTH; C-PTH: C-terminal PTH; PTH1 2R: PTH 1,2 receptor; cAMP: cyclic adenosine monophosphate; PLC: phospholipase C; PKA: protein kinase A; PKC: protein kinase C.
See this image and copyright information in PMC

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References

    1. Crane JL, Cao X. Bone marrow mesenchymal stem cells and tgf-beta signaling in bone remodeling. The Journal of clinical investigation. 2014;124:466–472. - PMC - PubMed
    1. Roche B, Vanden-Bossche A, Malaval L, Vico L, Normand M, Jannot M, Chaux R, Lafage-Proust MH. Parathyroid hormone 1–84 targets bone vascular structure and perfusion in mice: Impacts of its administration regimen and of ovariectomy. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2014 doi: 10.1002/jbmr.2191. Epub ahead of print. - DOI - PubMed
    1. Baron R, Hesse E. Update on bone anabolics in osteoporosis treatment: Rationale, current status, and perspectives. The Journal of clinical endocrinology and metabolism. 2012;97:311–325. - PMC - PubMed
    1. Clemens TL, Cormier S, Eichinger A, Endlich K, Fiaschi-Taesch N, Fischer E, Friedman PA, Karaplis AC, Massfelder T, Rossert J, Schluter KD, Silve C, Stewart AF, Takane K, Helwig JJ. Parathyroid hormone-related protein and its receptors: Nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets. British journal of pharmacology. 2001;134:1113–1136. - PMC - PubMed
    1. Macfarlane DP, Yu N, Leese GP. Subclinical and asymptomatic parathyroid disease: Implications of emerging data. The lancet Diabetes & endocrinology. 2013;1:329–340. - PubMed