Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014 Jul;34(7):1336-8.
doi: 10.1161/ATVBAHA.114.303877.

Endothelial cell global positioning system for pulmonary arterial hypertension: homing in on vascular repair

Natasha M Rogers  1 , Jeffrey S Isenberg  2
Affiliations
Editorial

Endothelial cell global positioning system for pulmonary arterial hypertension: homing in on vascular repair

Natasha M Rogers et al. Arterioscler Thromb Vasc Biol. 2014 Jul.
No abstract available

Keywords: interleukin-8; pulmonary artery hypertension; vascular repair.

PubMed Disclaimer

Conflict of interest statement

Disclosures: JSI is Chair of the SAB for Vasculox, Inc. and Radiation Control Technologies, Inc. and has equity interest in the same.

Figures

Figure 1
Figure 1. IL-8 receptor expressing endothelial cells reduces monocrotaline-mediated pulmonary inflammation and PAH
Monocrotaline (MCT) leads to endothelial cell (EC) injury, interstitial edema, and production of IL-8 by damaged EC and vascular smooth muscle cells (VSMC). The chemotactic cytokine attracts neutrophils (N) to the site of injury. Green fluorescent protein-positive EC transfected to express IL8RA/B and infused systemically at the time of MCT administration home to the site of injury to reduce inflammation, and participate in endothelial repair. F= fibroblast
See this image and copyright information in PMC

Comment on

References

    1. Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB. Definitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol. 2013;62:D42–50. - PubMed
    1. Benza RL, Miller DP, Barst RJ, Badesch DB, Frost AE, McGoon MD. An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry. Chest. 2012;142:448–456. - PubMed
    1. Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med. 2004;351:1425–1436. - PubMed
    1. Galie N, Corris PA, Frost A, Girgis RE, Granton J, Jing ZC, Klepetko W, McGoon MD, McLaughlin VV, Preston IR, Rubin LJ, Sandoval J, Seeger W, Keogh A. Updated treatment algorithm of pulmonary arterial hypertension. J Am Coll Cardiol. 2013;62:D60–72. - PubMed
    1. Farkas L, Kolb M. Vascular repair and regeneration as a therapeutic target for pulmonary arterial hypertension. Respiration. 2013;85:355–364. - PMC - PubMed

MeSH terms