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. 2015 Nov;29(6):427-31.
doi: 10.1002/jcla.21789. Epub 2014 Jun 21.

Evaluation of the Relationship Between Ischemia-Modified Albumin Levels and Thyroid Hormone Levels

Mufide Oncel  1 , Aysel Kıyıcı  1 , Serife Onen  2
Affiliations

Evaluation of the Relationship Between Ischemia-Modified Albumin Levels and Thyroid Hormone Levels

Mufide Oncel et al. J Clin Lab Anal. 2015 Nov.

Abstract

Background: A novel ischemia marker named ischemia modified albumin was previously considered as an early marker of myocardial ischemia, however due to recent reports, its contribution was demonstrated in different pathologies such as oxidative stress, diabetes, stroke and cancer. We aimed to investigate the relation between oxidative stress and thyroid dysfunctions determining IMA levels since IMA is closely related with increased oxidative stress.

Methods: A total of 88 individuals were participated in this study: 34 cases in hypothyroid, 27 cases in hyperthyroid and 27 cases in euthyroid group. Ischemia-modified albumin levels were measured by albumin cobalt binding test and thyroid hormone levels were determined with electrochemiluminescent method.

Results: Ischemia modified albumin levels were significantly decreased in hypothyroid group compared to hyperthyroid and euthyroid groups (p < 0.001). In hyperthyroid individuals ischemia modified albumin levels were higher compared to euthyroid ones (p < 0.001). Ischemia modified albumin was negatively correlated with TSH levels (r = -0.473, p < 0.001), and positively correlated with FT4 and FT3 levels (r = 0.496, p < 0.001 and r = 0.275, p = 0.010, respectively).

Conclusion: We suggest that albumin adjusted IMA levels are significantly lower in hypothyroid group than hyperthyroid and euthyroid groups.

Keywords: euthyroid; hyperthyroid; hypothyroid; ischemia-modified albumin; thyroid hormone levels.

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Figures

Figure 1
Figure 1
Scatter dot graph of TSH vs. albumin‐adjusted IMA. (Albumin‐adjusted IMA is negatively correlated with TSH. r = −0.456, p < 0.001)
Figure 2
Figure 2
Scatter dot graph of FT3 vs. albumin‐adjusted IMA. (Albumin adjusted IMA is positively correlated with FT3. r = 0.328, p = 0.002)
Figure 3
Figure 3
Scatter dot graph of FT4 vs. albumin‐adjusted IMA. (Albumin adjusted IMA is positively correlated with FT4. r = 0.466, p < 0.001)
See this image and copyright information in PMC

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References

    1. Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metabol 2002;87(2):489–499. - PubMed
    1. Makay B, Makay O, Yenisey C, et al. The interaction of oxidative stress response with cytokines in the thyrotoxic rat: Is there a link? Mediators Inflam 2009;2009:391682. - PMC - PubMed
    1. Coria1 MJ, Pastrán AI, Gimenez MS. Serum oxidative stress parameters of women with hypothyroidism. Acta Biomed 2009;80:135–139. - PubMed
    1. Bar‐Or D, Lau E, Rao N, Bampos N, Winkler JV, Curtis CG. Reduction in the cobalt binding capacity of human albumin with myocardial ischaemia. Ann Emer Med 1999;34(Suppl 4):1–5.
    1. Bar‐Or D, Curtis G, Rao N, Bampos N, Lau E. Characterization of the Co21 and Ni21 binding amino‐acid residues of the N‐terminus of human albumin. An insight into the mechanism of a new assay for myocardial ischemia. Eur J Biochem 2001;268:42–47. - PubMed

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