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. 2014;36(7):669-79.
doi: 10.1080/13803395.2014.925094. Epub 2014 Jun 23.

Feasibility of event-related potential methodology to evaluate changes in cortical processing after rehabilitation in children with cerebral palsy: a pilot study

Nathalie L Maitre  1 , Gena Henderson, Shirley Gogliotti, Jennifer Pearson, Ashley Simmons, Lu Wang, James C Slaughter, Alexandra P Key
Affiliations

Feasibility of event-related potential methodology to evaluate changes in cortical processing after rehabilitation in children with cerebral palsy: a pilot study

Nathalie L Maitre et al. J Clin Exp Neuropsychol. 2014.

Abstract

This study examined the feasibility of using event-related potentials (ERPs) to measure changes in cortical processing following an established rehabilitative intervention (constraint-induced movement therapy, CIMT) for children with cerebral palsy (CP). Sixteen participants with a diagnosis of hemiparetic CP, with a median age of 6 years, were assessed pre and immediately post CIMT and at 6-month follow-up, using a picture-word match/mismatch discrimination task and standard neurobehavioral measures. Intervention effects were evident in improved performance on behavioral tests of sensory and motor function and the increased mean ERP amplitude of the N400 match/mismatch response on the side ipsilateral to the lesion. These effects were maintained 6 months after the intervention. No such changes were observed on the side contralateral to the lesion. This research suggests that ERPs can measure rehabilitation-induced changes in neural function in children with CP.

Keywords: Cerebral palsy; Constraint therapy; Event-related potentials; Pediatric; Rehabilitation.

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Figures

Figure 1
Figure 1
Event-related potential (ERP) acquisition in children with hemiparetic cerebral palsy. (A) Electrode distribution in frontal clusters. (B) Child undergoing ERP. F3 indicates frontal left; F4 indicates frontal right.
Figure 2
Figure 2
Differences in picture–word match and mismatch responses in frontal locations in a representative subject. Response to match is traced in grey, mismatch in black. Panels are vertically arranged by Time 0 (baseline), Time 1 (immediately post CIMT), and Time 2 (6 months post CIMT). Panels are arranged horizontally by hemiscalp locations. Time post stimulus in ms is on the x-axis of each panel, mean amplitude in µV on the y-axis. Rectangle in each panel indicates N400 response window.
See this image and copyright information in PMC

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