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. 2014 Apr;3(2):118-22.
doi: 10.4103/2303-9027.131039.

Do the morphological features of walled off pancreatic necrosis on endoscopic ultrasound determine the outcome of endoscopic transmural drainage?

Surinder Singh Rana  1 , Deepak Kumar Bhasin  1 , Ravi Kumar Sharma  1 , Jeyashree Kathiresan  2 , Rajesh Gupta  3
Affiliations

Do the morphological features of walled off pancreatic necrosis on endoscopic ultrasound determine the outcome of endoscopic transmural drainage?

Surinder Singh Rana et al. Endosc Ultrasound. 2014 Apr.

Abstract

Background and objective: Endoscopic transmural drainage is an effective, but technically demanding treatment modality for walled off pancreatic necrosis (WOPN). The factors that determine the outcome of endoscopic treatment for WOPN have been infrequently studied. We aim to retrospectively correlate the morphological features of WOPN on endoscopic ultrasound (EUS) with the outcome of endoscopic transmural drainage.

Patients and methods: Over the last 3 years, 43 patients (36 males; mean age 36.04 ± 10.06 years) with symptomatic WOPN were treated by an attempted endoscopic drainage. The correlation between the morphological features of WOPN and the type of treatment offered as well as the number of endoscopic procedures undergone by the patient was assessed.

Results: The mean size of WOPN was 9.95 ± 2.75 cm with <10%, 10-40% and >40% solid debris being present in 6, 33, and 4 patients, respectively. Patients with <10% necrotic debris needed only single session of endoscopic drainage, whereas patients with 10-40% solid debris needed two or more sessions. Patients with >40% solid debris either needed direct endoscopic debridement or surgical necrosectomy. The extent of necrosis correlated significantly (r = 0.703, P < 0.001) with the type of treatment received by the patient. With increasing size of the collection (r = 0.320, P = 0.047) and the amount of the solid debris (r = 0.800, P < 0.001), there was a significant increase in the number of endoscopic procedures required for successful outcome by the patient.

Conclusions: The morphological features of WOPN on EUS have important therapeutic implications with collections having large size and more solid debris needing more aggressive therapeutic method for the successful outcome.

Keywords: Acute pancreatitis; computed tomography; endoscopic ultrasound; walled off pancreatic necrosis.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Walled off pancreatic necrosis with predominantly liquid content and was successfully treated with a single session of endoscopic transmural drainage
Figure 2
Figure 2
Walled off pancreatic necrosis with <40% solid content and needed three sessions of endoscopic transmural drainage with multiple stents and nasocystic catheter
Figure 3
Figure 3
Walled off pancreatic necrosis >40% solid necrotic debris and needed direct endoscopic necrosectomy
Figure 4
Figure 4
% solid necrotic debris in patients treated by endoscopic transluminal drainage or surgical drainage
See this image and copyright information in PMC

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