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Review
. 2014:2014:291862.
doi: 10.1155/2014/291862. Epub 2014 May 13.

Clinical genetics of Alzheimer's disease

Zhangyu Zou  1 , Changyun Liu  1 , Chunhui Che  1 , Huapin Huang  1
Affiliations
Review

Clinical genetics of Alzheimer's disease

Zhangyu Zou et al. Biomed Res Int. 2014.

Abstract

Alzheimer's disease (AD) is the most common progressive neurodegenerative disease and the most common form of dementia in the elderly. It is a complex disorder with environmental and genetic components. There are two major types of AD, early onset and the more common late onset. The genetics of early-onset AD are largely understood with mutations in three different genes leading to the disease. In contrast, while susceptibility loci and alleles associated with late-onset AD have been identified using genetic association studies, the genetics of late-onset Alzheimer's disease are not fully understood. Here we review the known genetics of early- and late-onset AD, the clinical features of EOAD according to genotypes, and the clinical implications of the genetics of AD.

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Figures

Figure 1
Figure 1
Potential pathways of susceptibility genes involved in the pathogenesis of AD.
See this image and copyright information in PMC

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