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. 2014 May 1;1(5):370-374.
doi: 10.1002/acn3.61.

Preventable Infections in Children with Leukodystrophy

Holly M Anderson  1 , Jacob Wilkes  2 , E Kent Korgenski  2 , Michael A Pulsipher  3 , Anne J Blaschke  4 , Adam L Hersh  4 , Rajendu Srivastava  5 , Joshua L Bonkowsky  6
Affiliations

Preventable Infections in Children with Leukodystrophy

Holly M Anderson et al. Ann Clin Transl Neurol. .

Abstract

Children with inherited leukodystrophies have high hospitalization rates, often associated with infection. We studied whether potentially modifiable risk factors (pre-existing in-dwelling central intravenous access, urinary catheter, hardware, or mechanical ventilation; and influenza vaccine) were associated with infection-related hospitalization in children with leukodystrophy. Central intravenous access was associated with sepsis (odds ratio (OR) 9.8); urinary catheter was associated with urinary tract infections (OR 9.0); lack of seasonal vaccination was associated with influenza (OR 6.4); and mechanical ventilation was associated with pneumonia (OR 2.7). We conclude that potentially modifiable risk factors are significantly associated with infection and hospitalization in children with leukodystrophies.

Keywords: Leukodystrophy; bronchiolitis; infection; influenza; pneumonia; sepsis.

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Figures

Figure 1
Figure 1
Odds ratios of modifiable risk factors for hospitalizations with infection. Odds ratios and 95% confidence intervals are shown. *P < 0.05; **P < 0.001. Along the y-axis, infection outcome is listed in bold with the risk factor in italics below.
See this image and copyright information in PMC

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