doi: 10.1016/0003-9861(89)90552-3.
A novel biosynthesis of medium chain length alpha-ketodicarboxylic acids in methanogenic archaebacteria
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- PMID: 2495771
- DOI: 10.1016/0003-9861(89)90552-3
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A novel biosynthesis of medium chain length alpha-ketodicarboxylic acids in methanogenic archaebacteria
Arch Biochem Biophys.
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Abstract
Gas chromatographic-mass spectrometric analysis on the distribution of alpha-ketodicarboxylic acids in various bacteria determined that alpha-ketoglutarate and alpha-ketoadipate are widely distributed in all the bacteria examined, whereas alpha-ketopimelate and alpha-ketosuberate are found only in the methanogenic archaebacteria. Labeling experiments with stable isotopes indicated that each of these acids arises from alpha-ketoglutarate by repeated alpha-ketoacid chain elongation. The final product in this series of reactions, alpha-ketosuberate, serves in the methanogenic bacteria as the biosynthetic precursor to the 7-mercaptoheptanoic acid portion of 7-mercaptoheptanoylthreonine phosphate, a methanogenic coenzyme.
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