Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Nov;92(2):123-32.
doi: 10.1016/j.critrevonc.2014.05.009. Epub 2014 Jun 4.

Adrenocortical carcinoma: the management of metastatic disease

André P Fay  1 , Aymen Elfiky  2 , Gabriela H Teló  3 , Rana R McKay  4 , Marina Kaymakcalan  4 , Paul L Nguyen  2 , Anand Vaidya  5 , Daniel T Ruan  2 , Joaquim Bellmunt  2 , Toni K Choueiri  6
Affiliations
Review

Adrenocortical carcinoma: the management of metastatic disease

André P Fay et al. Crit Rev Oncol Hematol. 2014 Nov.

Abstract

Adrenocortical cancer is a rare malignancy. While surgery is the cornerstone of the management of localized disease, metastatic disease is hard to treat. Cytotoxic chemotherapy and mitotane have been utilized with a variable degree of benefit and few long-term responses. A growing understanding of the molecular pathogenesis of this malignancy as well as multidisciplinary and multi-institutional collaborative efforts will result in better defined targets and subsequently, effective novel therapies.

Keywords: Adrenocortical carcinoma; Metastatic disease; Targeted therapies; Therapeutics.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow Diagram
See this image and copyright information in PMC

References

    1. Third national cancer survey: incidence data. National Cancer Institute monograph. 1975 Mar;(41):i–x. 1–454. - PubMed
    1. Kebebew E, Reiff E, Duh QY, Clark OH, McMillan A. Extent of disease at presentation and outcome for adrenocortical carcinoma: have we made progress? World journal of surgery. 2006 May;30(5):872–878. - PubMed
    1. Koschker AC, Fassnacht M, Hahner S, Weismann D, Allolio B. Adrenocortical carcinoma -- improving patient care by establishing new structures. Experimental and clinical endocrinology & diabetes: official journal, German Society of Endocrinology [and] German Diabetes Association. 2006 Feb;114(2):45–51. - PubMed
    1. Pianovski MA, Maluf EM, de Carvalho DS, et al. Mortality rate of adrenocortical tumors in children under 15 years of age in Curitiba, Brazil. Pediatric blood & cancer. 2006 Jul;47(1):56–60. - PubMed
    1. Figueiredo BC, Sandrini R, Zambetti GP, et al. Penetrance of adrenocortical tumours associated with the germline TP53 R337H mutation. Journal of medical genetics. 2006 Jan;43(1):91–96. - PMC - PubMed

Publication types

MeSH terms

Substances