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Case Reports
. 2014 Jan;18(1):102-6.
doi: 10.4103/0973-029X.131927.

Primary diffuse large B-cell lymphoma in the anterior hard palate: A rare case report with review of literature

Sujit Ranjan Sahoo  1 , Satya Ranjan Misra  2 , Lora Mishra  3 , Sobhan Mishra  4
Affiliations
Case Reports

Primary diffuse large B-cell lymphoma in the anterior hard palate: A rare case report with review of literature

Sujit Ranjan Sahoo et al. J Oral Maxillofac Pathol. 2014 Jan.

Abstract

Diffuse large B-cell lymphomas (DLBCLs) are defined as neoplasms of large transformed B cells, i.e. with nuclear diameter more than twice that of a normal lymphocyte. These account for 30-40% of all adult non-Hodgkin's lymphomas (NHL). Intraoral lymphomas are relatively rare and often difficult to diagnose in clinical settings. In this case report, we describe a case of primary DLBCL affecting the anterior part of the hard palate of an elderly male patient. DLBCL of anterior part of hard palate is yet to be reported in the English literature, even though DLBCL cases involving the posterior palate have been recorded, thus making the present case to be first of its kind. Emphasis has also been given on the subclassification, differential diagnosis and prognostic antibody factors determining the outcome of DLBCL.

Keywords: Anterior hard palate; diffuse large B-cell lymphoma; non-Hodgkin's lymphoma.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Swelling in the anterior hard palate with surface ulceration
Figure 2
Figure 2
CT scan of the maxilla, sagittal, (a) coronal (b) and axial (c) sections showing a space occupying hypodense lesion in the anterior maxilla (red arrow) with perforation and extension into the maxillary antrum. CT: Computed tomography
Figure 3
Figure 3
Photomicrograph showing centroblasts (red arrows), i.e. large atypical pleomorphic lymphocytic nucleus with multiple nucleoli (H & E stain, ×400)
Figure 4
Figure 4
CD20 immunostaining showing strong positivity indicating B-cell origin of lymphocytes (IHC stain, ×200)
Figure 5
Figure 5
Post-chemotherapy photo showing complete resolution of the lesion followed by hypermelanosis after resolution of the swelling (red arrow)
See this image and copyright information in PMC

References

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