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Review
. 2014 Jun 1;6(1):e2014039.
doi: 10.4084/MJHID.2014.039. eCollection 2014.

Immunological deregulation in classic hodgkin lymphoma

Alessandra Romano  1 , Calogero Vetro  1 , Giovanni Caocci  2 , Marianna Greco  2 , Nunziatina Laura Parrinello  1 , Francesco Di Raimondo  1 , Giorgio La Nasa  2
Affiliations
Review

Immunological deregulation in classic hodgkin lymphoma

Alessandra Romano et al. Mediterr J Hematol Infect Dis. .

Abstract

Classic Hodgkin Lymphoma (cHL) has a unique histology since only a few neoplastic cells are surrounded by inflammatory accessory cells that in the last years have emerged as crucial players in sustaining the course of disease. In addition, recent studies suggest that the abnormal activity of these inflammatory cells (such as deregulation in regulatory T cells signaling, expansion of myeloid derived suppressor cells, HLA-G signaling and natural killer cells dysfunction) may have prognostic significance. This review is focused on summarizing recent advanced in immunological defects in cHL with translational implications.

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