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. 2014 Apr;5(2):96-103.
doi: 10.4103/2231-4040.133436.

Effect of novel mucoadhesive buccal patches of carvedilol on isoprenaline-induced tachycardia

Navneet Verma  1 , Pronobesh Chattopadhyay  2
Affiliations

Effect of novel mucoadhesive buccal patches of carvedilol on isoprenaline-induced tachycardia

Navneet Verma et al. J Adv Pharm Technol Res. 2014 Apr.

Abstract

The main aim of the study was designed to develop bioadhesive buccal patches of carvedilol (CR) and evaluate for isoprenaline-induced tachycardia. Buccal patches of carvedilol were prepared by using chitosan (CH), sodium salt of carboxy methyl cellulose (NaCMC), and polyvinyl alcohol (PVA) as mucoadhesive polymers. The solvent evaporation method was used for the preparation of buccal patches. The patches were evaluated for their physical characteristics like patch thickness, weight variation, content uniformity, folding endurance, surface pH, residence time, in vitro drug release, and in vivo pharmacodynamic study. The swelling index of the patches was found to be proportional to the polymer concentration, whereas surface pH of all the formulated bioadhesive patches was found to lie between neutral ranges. In-vitro release study shows that 94.75% drug was release in 8 hours from the patch, which containing 2% w/v chitosan. The folding endurance result shows good elasticity in all the patches. Application of buccal patches on buccal mucosa of rabbit shows a significant result in % inhibition of isoprenaline-induced tachycardia. Prepared buccal patches of chitosan, NaCMC, and PVA containing Carvedilol meet the ideal requirement for the delivery of cardiovascular drugs and inhibit the isoprenaline tachycardia.

Keywords: Buccal; carvedilol; folding endurance; tachycardia.

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Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
% Swelling of chitosan, NaCMC, and PVA patches containing carvedilol
Figure 2
Figure 2
Residence time of mucoadhesive buccal patch containing carvedilol
Figure 3
Figure 3
In-vitro cumulative % release of CR from various buccal patches in phosphate buffer pH 6.8 at 37 ± 0.5°C
Figure 4
Figure 4
Scanning electron micrographs of optimized buccal patches (a) CC-2 (b) SC-3 (c) PC-2
See this image and copyright information in PMC

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