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. 2013 Jun 23:2013:280395.
doi: 10.5402/2013/280395. eCollection 2013.

Vitamin e is a nephroprotectant agent in male but not in female in a model of Cisplatin-induced nephrotoxicity

Sima Jilanchi  1 , Mehdi Nematbakhsh  2 , Mehrnoosh Bahadorani  3 , Ardeshir Talebi  4 , Fatemeh Eshraghi-Jazi  5 , Azam Mansouri  5 , Farzaneh Ashrafi  6
Affiliations

Vitamin e is a nephroprotectant agent in male but not in female in a model of Cisplatin-induced nephrotoxicity

Sima Jilanchi et al. ISRN Nephrol. .

Abstract

Background. The role of gender for nephroprotectant agent such as vitamin E in cisplatin- (CP-) induced nephrotoxicity has not been documented yet. Methods. One group from each gender of Wistar rats received a single dose of CP (7 mg/kg; i.p) and was treated with vitamin E (1 g/kg/day) for 7 days, and they were compared with similar gender in the control group. Results. The serum levels of blood urea nitrogen (BUN) and creatinine (Cr) in male animals treated with CP was not different from the control group, but it was significantly different in the female rats (P < 0.05). The CP-induced damage intensity in male kidney tissue was not significantly different between the CP-treated and control groups, but this was not the case in female, indicating that the tissue damage in female is significantly different from the control group (P < 0.05). No significant difference in serum levels of magnesium (Mg), nitrite, malondialdehyde (MDA), and lactate dehydrogenase (LDH) was seen between the genders. Kidney weight and body weight changes were statistically significant in both genders (P < 0.05). Significant difference was observed in uterus weight between the two groups of female (P < 0.05). Conclusion. Vitamin E may prevent CP-induced nephrotoxicity in male, but possibly it has not such nephroprotectant effect in female.

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Figures

Figure 1
Figure 1
(a) Blood urea nitrogen (BUN), (b) creatinine, (c) lactate dehydrogenase (LDH), and (d) magnesium (Mg) levels in serum, (e) kidney tissue levels of malondialdehyde (MDA) and (f): nitrite, and serum levels of (g) nitrite and (h) MDA in four experimental groups of animals treated with CP and vitamin E. E + CPM, E + CPFE, EM, and EFE stand for the group names: males treated with vitamin E and CP, females treated with vitamin E and CP, males treated with vitamin E alone, and females treated with vitamin E alone, respectively.
Figure 2
Figure 2
(a) Kidney weight (KW), (b) kidney damage score, (c) uterus/testis weight, and (d) percentage of weight change in four experimental groups of animals treated with CP and vitamin E. E + CPM, E + CPFE, EM, and EFE stand for the group names: males treated with vitamin E and CP, females treated with vitamin E and CP, males treated with vitamin E alone, and females treated with vitamin E alone, respectively.
Figure 3
Figure 3
The images of kidney tissues (magnification ×100) in all groups of experiments. E + CPM, E + CPFE, EM, and EFE stand for the group names: males treated with vitamin E and CP, females treated with vitamin E and CP, males treated with vitamin E alone, and females treated with vitamin E alone, respectively. More kidney tissue damage was observed in groups E + CPFE.
See this image and copyright information in PMC

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