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Review
. 2014:2014:648459.
doi: 10.1155/2014/648459. Epub 2014 May 18.

The ECM-cell interaction of cartilage extracellular matrix on chondrocytes

Yue Gao  1 , Shuyun Liu  1 , Jingxiang Huang  1 , Weimin Guo  1 , Jifeng Chen  1 , Li Zhang  1 , Bin Zhao  1 , Jiang Peng  1 , Aiyuan Wang  1 , Yu Wang  1 , Wenjing Xu  1 , Shibi Lu  1 , Mei Yuan  1 , Quanyi Guo  1
Affiliations
Review

The ECM-cell interaction of cartilage extracellular matrix on chondrocytes

Yue Gao et al. Biomed Res Int. 2014.

Abstract

Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS). Articular cartilage ECM plays a crucial role in regulating chondrocyte metabolism and functions, such as organized cytoskeleton through integrin-mediated signaling via cell-matrix interaction. Cell signaling through integrins regulates several chondrocyte functions, including differentiation, metabolism, matrix remodeling, responses to mechanical stimulation, and cell survival. The major signaling pathways that regulate chondrogenesis have been identified as wnt signal, nitric oxide (NO) signal, protein kinase C (PKC), and retinoic acid (RA) signal. Integrins are a large family of molecules that are central regulators in multicellular biology. They orchestrate cell-cell and cell-matrix adhesive interactions from embryonic development to mature tissue function. In this review, we emphasize the signaling molecule effect and the biomechanics effect of cartilage ECM on chondrogenesis.

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