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Case Reports
. 1989 Jan;148(4):312-4.
doi: 10.1007/BF00444121.

Fatal graft versus host disease after platelet transfusions in a child with purine nucleoside phosphorylase deficiency

S Strobel  1 , G Morgan, A H Simmonds, R J Levinsky
Affiliations
Case Reports

Fatal graft versus host disease after platelet transfusions in a child with purine nucleoside phosphorylase deficiency

S Strobel et al. Eur J Pediatr. 1989 Jan.

Abstract

Fatal graft versus host disease (GVHD) developed in a child with purine nucleoside phosphorylase (PNP) deficiency following an unirradiated platelet transfusion. IV treatment with an anti-T-cell monoclonal antibody (CD7) led to a transient improvement of his GVHD (Grade IV) but did not prevent the fatal outcome. This report emphasizes the need for blood products to be irradiated when cell mediated immunodeficiency is suspected, even in patients with residual immunocompetence.

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