Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jul 1;2012(7):11.
doi: 10.1093/jscr/2012.7.11.

Splenic rupture following thrombolysis treatment for acute myocardial infarction

Affiliations

Splenic rupture following thrombolysis treatment for acute myocardial infarction

Rl Harries et al. J Surg Case Rep. .

Abstract

Thrombolysis is the gold standard of treatment for acute myocardial infarction (MI), however can be associated with haemorrhagic complications. To date, splenic rupture following thrombolysis has only been reported in those with an associated history of major trauma or splenomegaly. We report a case of a 47-year old female who developed splenic rupture following thrombolysis treatment with no history of trauma or splenomegaly. She received Tenecteplase therapy for an inferior MI, and six hours later she developed upper abdominal pain and hypotension. CT showed large haemoperitoneum with a large peri-splenic haematoma. She subsequently underwent a laparotomy and splenectomy. Patient remained well and was discharged home eight days postoperatively.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Computed Tomography (CT) of abdomen and pelvis scan demonstrating large haemoperitoneum with a large peri-splenic haematoma

References

    1. National Institute of Clinical Excellence. Guidance on the use of drugs for early thrombolysis in the treatment of acute myocardial infarction (2002) www.nice.org.uk/nicemedia/live/11480/32504/32504.pdf
    1. The GUSTO Investigators An international randomised trial comparing four thrombolytic strategies for acute myocardial infarction and venous thromboembolism. N Engl J Med 1993; 329: 673–82 - PubMed
    1. Lauer J, Heger J, Mirr M. Haemorrhagic complications of thrombolytic therapy. Chest 1995; 108: 1520–3 - PubMed
    1. Berkowitz SD, Granger CB, Pieper KS, Lee KL, Gore JM, Simmoons M, Armstrong PW, Topol EJ, Califf RM. Incidence and predictors of bleeding after contemporary thrombolytic therapy for myocardial infarction. The Global Utilization of Streptokinase and Tissue Plasminogen activator for Occluded coronary arteries (GUSTO) I Investigators. Circulation 1997; 95: 2508–16 - PubMed
    1. Nam R, Carr MM, Jamieson CG. Delayed rupture of the spleen and streptokinase therapy. Can J Surg 1996; 39(2):151–4 - PMC - PubMed