doi: 10.1111/j.1471-4159.1989.tb09192.x.
Dopamine release in rat striatum: physiological coupling to tyrosine supply
Affiliations
- PMID: 2496199
- DOI: 10.1111/j.1471-4159.1989.tb09192.x
Item in Clipboard
Dopamine release in rat striatum: physiological coupling to tyrosine supply
J Neurochem.
1989 May.
Abstract
Intracerebral microdialysis was used to monitor dopamine release in rat striatal extracellular fluid following the intraperitoneal administration of dopamine's precursor amino acid, L-tyrosine. Dopamine concentrations in dialysates increased transiently after tyrosine (50-100 mg/kg) administration. Pretreatment with haloperidol or the partial lesioning of nigrostriatal neurons enhanced the effect of tyrosine on dopamine release, and haloperidol also prolonged this effect. These data suggest that nigrostriatal dopaminergic neurons are responsive to changes in precursor availability under basal conditions, but that receptor-mediated feedback mechanisms limit the magnitude and duration of this effect.
Similar articles
-
Dopamine synthesis in rat striatum: mobilization of tyrosine from non-dopaminergic cells.Experientia. 1987 Oct 15;43(10):1109-10. doi: 10.1007/BF01956051. Experientia. 1987. PMID: 3117583
-
Effects of haloperidol administration on in vivo extracellular dopamine in striatum and prefrontal cortex after partial dopamine lesions.Brain Res. 1991 May 17;549(1):155-8. doi: 10.1016/0006-8993(91)90613-z. Brain Res. 1991. PMID: 1909923
-
Effects of systemic L-tyrosine on dopamine release from rat corpus striatum and nucleus accumbens.Brain Res. 1988 Jun 14;452(1-2):378-80. doi: 10.1016/0006-8993(88)90043-1. Brain Res. 1988. PMID: 3401745
-
Contribution to the study of nigrostriatal dopaminergic neuron activity using electrochemical detection of dopamine release in the striatum of freely moving animals.Ann N Y Acad Sci. 1986;473:126-40. doi: 10.1111/j.1749-6632.1986.tb23609.x. Ann N Y Acad Sci. 1986. PMID: 3099623 Review. No abstract available.
-
Control of sensorimotor function by dopaminergic nigrostriatal neurons: influence on eating and drinking.Neurosci Biobehav Rev. 1986 Spring;10(1):15-36. doi: 10.1016/0149-7634(86)90030-8. Neurosci Biobehav Rev. 1986. PMID: 3010199 Review.
Cited by
-
Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses.Nutr Rev. 2010 Dec;68 Suppl 2(Suppl 2):S88-101. doi: 10.1111/j.1753-4887.2010.00344.x. Nutr Rev. 2010. PMID: 21091953 Free PMC article. Review.
-
In rats chronically treated with clozapine, tyrosine depletion attenuates the clozapine-induced in vivo increase in prefrontal cortex dopamine and norepinephrine levels.Psychopharmacology (Berl). 2006 May;185(4):416-22. doi: 10.1007/s00213-005-0283-1. Epub 2006 Mar 16. Psychopharmacology (Berl). 2006. PMID: 16541248
-
Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease.Oxid Med Cell Longev. 2017;2017:4829180. doi: 10.1155/2017/4829180. Epub 2017 Jul 12. Oxid Med Cell Longev. 2017. PMID: 28785375 Free PMC article. Review.
-
Differential modulation of dopaminergic systems in the rat brain by dietary protein.Neurochem Res. 1994 Feb;19(2):167-76. doi: 10.1007/BF00966812. Neurochem Res. 1994. PMID: 8183426
-
The catecholamine neurotransmitter precursor tyrosine increases anger during exposure to severe psychological stress.Psychopharmacology (Berl). 2015 Mar;232(5):943-51. doi: 10.1007/s00213-014-3727-7. Epub 2014 Sep 16. Psychopharmacology (Berl). 2015. PMID: 25220844 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
