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Review
. 2014 Jul;74(10):1153-63.
doi: 10.1007/s40265-014-0252-2.

Vorapaxar: first global approval

Raewyn M Poole  1 , Shelley Elkinson
Affiliations
Review

Vorapaxar: first global approval

Raewyn M Poole et al. Drugs. 2014 Jul.

Abstract

Vorapaxar [Zontivity(®) (US)], an orally active protease-activated receptor-1 (PAR-1) receptor antagonist, has been developed by Merck & Co for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). Vorapaxar has received its first global approval for this indication in the US. This article summarizes the milestones in the development of vorapaxar leading to this first approval for the reduction of thrombotic cardiovascular events in patients with a prior MI or PAD.

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References

    1. Vasc Health Risk Manag. 2014 Apr 03;10:177-88 - PubMed
    1. Thromb Haemost. 2014 May 5;111(5):883-91 - PubMed
    1. Stroke. 2013 Mar;44(3):691-8 - PubMed
    1. Clin Pharmacol Drug Dev. 2013 Jan;2(1):90-8 - PubMed
    1. Circulation. 2011 May 10;123(18):e426-579 - PubMed

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