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Case Reports
. 2014 Jul;20(7):1199-202.
doi: 10.3201/eid2007.140155.

Severe malaria not responsive to artemisinin derivatives in man returning from Angola to Vietnam

Nguyen Van Hong, Alfred Amambua-Ngwa, Nguyen Quang Tuan, Do Duy Cuong, Nguyen Thi Huong Giang, Nguyen Van Dung, Ta Thi Tinh, Nguyen Van Tien, Bui Quang Phuc, Tran Thanh Duong, Anna Rosanas-Urgell, Umberto D'Alessandro, Jean-Pierre Van Geertruyden, Annette Erhart
Case Reports

Severe malaria not responsive to artemisinin derivatives in man returning from Angola to Vietnam

Nguyen Van Hong et al. Emerg Infect Dis. 2014 Jul.

Abstract

Resistance to artemisinin derivatives, the most potent antimalarial drugs currently used, has emerged in Southeast Asia and threatens to spread to Africa. We report a case of malaria in a man who returned to Vietnam after 3 years in Angola that did not respond to intravenous artesunate and clindamycin or an oral artemisinin-based combination.

Keywords: Angola; Plasmodium falciparum; Vietnam; artemisinins; cerebral malaria; drug resistance; malaria; parasites; severe malaria; travel medicine.

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Figures

Figure 1
Figure 1
Evolution of Plasmodium falciparum parasite density (log scale) by day after start of antimalaria treatments for man with severe malaria who returned from Angola to Vietnam in April 2013. Values are parasites/microliter of blood. IV, intravenous.
Figure 2
Figure 2
Clonal complexity of Plasmodium falciparum strain that caused severe malaria in man who returned from Angola to Vietnam after treatment, as determined by merozoite surface protein 1 (MSP1) and MSP2 repeat length molecular typing. Allele sizes were detected by capillary electrophoresis of amplified MSP repeat regions and shown for each follow-up sample.
See this image and copyright information in PMC

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References

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