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Review
. 2014 Sep;11(3):260-5.
doi: 10.1007/s11897-014-0208-6.

ROSE-AHF and lessons learned

Amit K Jain  1 , Horng H Chen
Affiliations
Review

ROSE-AHF and lessons learned

Amit K Jain et al. Curr Heart Fail Rep. 2014 Sep.

Abstract

Nesiritide and dopamine have been recognized for some time as potential renal adjunct therapies in the management of patients with acute heart failure (AHF). Several studies have yielded conflicting evidence of the efficacy of both medications in enhancing the renal function of patients with AHF. The Renal Optimization Strategies Evaluation (ROSE) study was a multicenter double-blind placebo controlled trial designed to assess the potential renoprotective effects of low-dose nesiritide and dopamine in AHF patients with renal dysfunction. This article will focus on previous research, summary of results, and lessons learned from the ROSE-AHF trial as well as future directions for clinical research and applications.

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Conflict of interest statement

Conflict of Interest

Amit K. Jain declares that he has no conflict of interest.

Horng H. Chen has received financial support through grants from the National Institutes of Health (NIH) and Scios, Inc.; has received royalties from Nile Therapeutics, Anexon, and UpToDate; holds the patent issued for chimeric natriuretic peptides; and is the co-founder of Zumbro Discovery.

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