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. 2014 Jul;29(3):345-50.
doi: 10.1007/s12291-013-0380-6. Epub 2013 Sep 8.

Serum Levels of Glycoproteins are Elevated in Patients with Ovarian Cancer

Vikram Thakkar  1 , Purvi Patel  2 , Neelam Prajapati  2 , Ranjit Kaur  1 , Mukesh Nandave  3
Affiliations

Serum Levels of Glycoproteins are Elevated in Patients with Ovarian Cancer

Vikram Thakkar et al. Indian J Clin Biochem. 2014 Jul.

Abstract

Identification of reliable biomarkers for detection and staging of cancer and monitoring the outcome of anticancer therapy has been considered to be of high importance. We aimed to estimate the levels of serum glycoproteins, protein bound-hexose, protein bound hexosamine, protein bound fucose, protein bound sialic acid and protein bound carbohydrate in 32 ovarian cancer patients and compared them with the levels that found in 25 normal subjects. As compared to the normal subjects, all the four fractions of glycoproteins level were significantly elevated in ovarian cancer patients (p < 0.05). Chemotherapy in these patients significantly decreased the levels of serum glycoproteins (p < 0.05). Thus, high levels of serum glycoproteins in ovarian cancer patients could be due to abnormal protein glycosylation indicating malignant transformation of the cells.

Keywords: Glycoproteins; Ovarian cancer; Protein bound carbohydrate; Protein bound hexosamine; Serum hexose; Sialic acid.

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Figures

Fig. 1
Fig. 1
ROC curves assessing overall diagnostic abilities of serum glycoprotein markers. Diagonal segments are produced by ties
See this image and copyright information in PMC

References

    1. Puig PL, Béroud C, Soussi T. APC gene: database of germline 29 and somatic mutations in human tumors and cell lines. Nucleic Acids Res. 1998;26:269–270. doi: 10.1093/nar/26.1.269. - DOI - PMC - PubMed
    1. Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer. 2011;11:426–437. doi: 10.1038/nrc3066. - DOI - PubMed
    1. Wang Q, Chaerkady R, Wu J, Hwang HJ, Papadopoulos N, Kopelovich L, Maitra A, Matthaei H, Eshleman JR, Hruban RH, Kinzler KW, Pandey A, Vogelstein B. Mutant proteins as cancer-specific biomarkers. Proc Natl Acad Sci USA. 2011;108:2444–2449. doi: 10.1073/pnas.1019203108. - DOI - PMC - PubMed
    1. Bhatt AN, Mathur R, Farooque A, Verma A, Dwarakanath BS. Cancer biomarkers—Current perspectives. Indian J Med Res. 2010;132:129–149. - PubMed
    1. Fernandis AZ, Wenk MR. Lipid-based biomarkers for cancer. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877:2830–2835. doi: 10.1016/j.jchromb.2009.06.015. - DOI - PubMed