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. 2014 Jun;64(3):175-9.
doi: 10.1007/s13224-014-0512-9. Epub 2014 Mar 12.

A comparative study of oxytocin/misoprostol/methylergometrine for active management of the third stage of labor

Megha Sharma  1 , Parneet Kaur  1 , Khushpreet Kaur  1 , Arvinder Kaur  1 , Preet Kanwal Kaur  1 , Mohi Manjit Kaur  1
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A comparative study of oxytocin/misoprostol/methylergometrine for active management of the third stage of labor

Megha Sharma et al. J Obstet Gynaecol India. 2014 Jun.

Abstract

Objectives: To study oxytocin, misoprostol, and methylergometrine in active management of the third stage of labor and determine duration of the third stage of labor, blood loss, adverse effects, and need for additional uterotonics in each group.

Methods: Clinical trial of 300 women with healthy singleton pregnancy allocated into three groups to receive either: 10 IU intravenous oxytocin infusion, 600 μg sublingual misoprostol, or 200 μg intravenous methylergometrine. Primary outcome measure was blood loss in the third stage of labor; secondary measures were duration of the third stage, side effects, and complications.

Results: Subjects who received 600 μg of misoprostol had the least blood loss, followed by oxytocin, and methylergometrine. The shortest mean duration of the third stage was with misoprostol. Shivering and pyrexia were observed in misoprostol group, and raised blood pressure in methylergometrine group.

Conclusions: Misoprostol is as effective as oxytocin and both are more effective than methylergometrine in active management of the third stage of labor.

Keywords: Active management; PPH; Third stage.

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References

    1. Kaul V, Bagga R, Jain V, et al. The impact of primary postpartum hemorrhage in “Near-Miss” morbidity and mortality in a tertiary care hospital in North India. Indian J Med Sci. 2006;60:233–240. doi: 10.4103/0019-5359.25905. - DOI - PubMed
    1. Mathai M, Gülmezoglu A, Hill S. WHO recommendations for the prevention of postpartum hemorrhage. Geneva: WHO Document Production Services; 2007. pp. 4–5.
    1. Soltan MH, El-Gendi E, Imam HH, et al. Different doses of sublingual misoprostol versus methylergometrine for the prevention of atonic postpartum hemorrhage. Int J Health Sci (Qassim) 2007;1(2):229–236. - PMC - PubMed
    1. Tang OS, Schweer H, Seyberth HW, et al. Pharmacokinetics of different routes of administration of misoprostol. Hum Reprod. 2002;17(2):332–336. doi: 10.1093/humrep/17.2.332. - DOI - PubMed
    1. Ng PS, Chan AS, Sin WK, et al. A multicentre randomized controlled trial of oral misoprostol and i.m. syntometrine in the management of the third stage of labor. Hum Reprod. 2001;16(1):31–35. doi: 10.1093/humrep/16.1.31. - DOI - PubMed

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