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. 2014 Jun;64(3):202-7.
doi: 10.1007/s13224-014-0515-6. Epub 2014 Feb 27.

Estradiol Level on Day 2 and Day of Trigger: A Potential Predictor of the IVF-ET Success

Sudha Prasad  1 , Yogesh Kumar  1 , Megha Singhal  1 , Shashi Sharma  2
Affiliations

Estradiol Level on Day 2 and Day of Trigger: A Potential Predictor of the IVF-ET Success

Sudha Prasad et al. J Obstet Gynaecol India. 2014 Jun.

Abstract

Objective: To evaluate role of serum estradiol levels in predicting likelihood of pregnancy in women undergoing GnRH-a protocol in IVF-ET cycles.

Design: A 3-year retrospective analysis of estradiol levels on down-regulated day 2, day 6, and day of hCG trigger and subsequent clinical pregnancy rates.

Setting: A university hospital tertiary referral centre.

Population or sample: Women undergoing IVF treatment.

Methods: Hormonal assessment on the down-regulated day 2, day 6, and day of hCG trigger.

Main outcome measures: Comparison of hormonal profile, antral follicular count on day 2, endometrial thickness on day of trigger, and number of oocytes retrieved between pregnant and the non-pregnant group. The prediction of IVF success was based on the quantitative levels of estradiol on a specific day in down-regulated cycle.

Results: The overall pregnancy rate was 32.25 % (50/160). Estradiol level on down-regulated day 2 was 31.9 ± 12.6 and on the day of trigger was 1,996.46 ± 1,252.36 in pregnant women, which was significantly higher as compared to estradiol levels in non-pregnant women (27.6 ± 12.3 and 1,525.1 ± 1,116.42, respectively). It was found to be a significant prognostic marker for successful IVF treatment. Estradiol levels on down-regulated day 6 were found to be non-significant between the two groups.

Conclusions: Estradiol level on down-regulated day 2 of menstrual cycle and on the day of trigger was found to have a significant impact on the success of IVF-ET.

Keywords: Day 2; Day 6; Day of hCG trigger; Estradiol; IVF outcome.

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Figures

Fig. 1
Fig. 1
Comparison of estimated marginal mean estradiol levels between Group A and Group B
Fig. 2
Fig. 2
ROC curve of estradiol levels on day 2 and day of hCG trigger in Group A (pregnant group) forecasting the likelihood of the pregnancy in IVF procedure
Fig. 3
Fig. 3
ROC curve of estradiol levels on day 2 and day of hCG trigger in Group B (non-pregnant group) forecasting the likelihood of the pregnancy in IVF procedure
See this image and copyright information in PMC

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