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. 1989 Jan;33(1):124-7.
doi: 10.1128/AAC.33.1.124.

Outer membrane alterations in multiresistant mutants of Pseudomonas aeruginosa selected by ciprofloxacin

N J Legakis  1 , L S Tzouvelekis, A Makris, H Kotsifaki
Affiliations

Outer membrane alterations in multiresistant mutants of Pseudomonas aeruginosa selected by ciprofloxacin

N J Legakis et al. Antimicrob Agents Chemother. 1989 Jan.

Abstract

Spontaneous mutants of Pseudomonas aeruginosa selected by ciprofloxacin were studied for outer membrane alterations. Acquisition of ciprofloxacin resistance was at least partially related to defects in lipopolysaccharide synthesis. When ciprofloxacin resistance was combined with resistance to beta-lactams and aminoglycosides, several alterations in outer membrane proteins were noted.

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References

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