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Review
. 2014 Jun 9:7:219-30.
doi: 10.2147/IJNRD.S42054. eCollection 2014.

Hypomagnesemia: a clinical perspective

Phuong-Chi T Pham  1 , Phuong-Anh T Pham  2 , Son V Pham  3 , Phuong-Truc T Pham  4 , Phuong-Mai T Pham  5 , Phuong-Thu T Pham  6
Affiliations
Review

Hypomagnesemia: a clinical perspective

Phuong-Chi T Pham et al. Int J Nephrol Renovasc Dis. .

Abstract

Although magnesium is involved in a wide spectrum of vital functions in normal human physiology, the significance of hypomagnesemia and necessity for its treatment are under-recognized and underappreciated in clinical practice. In the current review, we first present an overview of the clinical significance of hypomagnesemia and normal magnesium metabolism, with a focus on renal magnesium handling. Subsequently, we review the literature for both congenital and acquired hypomagnesemic conditions that affect the various steps in normal magnesium metabolism. Finally, we present an approach to the routine evaluation and suggested management of hypomagnesemia.

Keywords: TRPM6; alcohol; cisplatin; diabetes mellitus; hypomagnesemia; magnesium.

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Figures

Figure 1
Figure 1
Number of PubMed citations (November 2013).
Figure 2
Figure 2
Kidney handling of magnesium. Abbreviations: CLD, claudin; TRPM6, transient receptor potential channel 6.
Figure 3
Figure 3
Magnesium reabsorption at the distal convoluted tubule.
See this image and copyright information in PMC

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