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. 2014 Jun 12:6:199-211.
doi: 10.2147/CLEP.S60991. eCollection 2014.

The Copenhagen Primary Care Differential Count (CopDiff) database

Christen Lykkegaard Andersen  1 , Volkert Dirk Siersma  2 , Willy Karlslund  2 , Hans Carl Hasselbalch  3 , Peter Felding  4 , Ole Weis Bjerrum  5 , Niels de Fine Olivarius  2
Affiliations

The Copenhagen Primary Care Differential Count (CopDiff) database

Christen Lykkegaard Andersen et al. Clin Epidemiol. .

Abstract

Background: The differential blood cell count provides valuable information about a person's state of health. Together with a variety of biochemical variables, these analyses describe important physiological and pathophysiological relations. There is a need for research databases to explore associations between these parameters, concurrent comorbidities, and future disease outcomes.

Methods and results: The Copenhagen General Practitioners' Laboratory is the only laboratory serving general practitioners in the Copenhagen area, covering approximately 1.2 million inhabitants. The Copenhagen General Practitioners' Laboratory has registered all analytical results since July 1, 2000. The Copenhagen Primary Care Differential Count database contains all differential blood cell count results (n=1,308,022) from July 1, 2000 to January 25, 2010 requested by general practitioners, along with results from analysis of various other blood components. This data set is merged with detailed data at a person level from The Danish Cancer Registry, The Danish National Patient Register, The Danish Civil Registration System, and The Danish Register of Causes of Death.

Conclusion: This paper reviews methodological issues behind the construction of the Copenhagen Primary Care Differential Count database as well as the distribution of characteristics of the population it covers and the variables that are recorded. Finally, it gives examples of its use as an inspiration to peers for collaboration.

Keywords: differential leukocyte count; nationwide health registers; research.

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Figures

Figure 1
Figure 1
Flowchart. Abbreviations: CGPL, Copenhagen General Practitioners’ Laboratory; CopDiff, Copenhagen Primary Care Differential Count; CRS, Danish Civil Registration System; DIFF, differential cell count; GP, general practitioner.
See this image and copyright information in PMC

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