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. 2014 Apr 15;7(5):2402-10.
eCollection 2014.

Notch-1 and Ki-67 receptor as predictors for the recurrence and prognosis of Kimura's disease

Wei-Ye Deng  1 , Shu-Biao Ye  2 , Rong-Zhen Luo  3 , Shu-Mei Yan  3 , Yun-Fei Gao  1 , Yuan-Zhong Yang  3 , Zhu-Ming Guo  1 , Yan-Feng Chen  1
Affiliations

Notch-1 and Ki-67 receptor as predictors for the recurrence and prognosis of Kimura's disease

Wei-Ye Deng et al. Int J Clin Exp Pathol. .

Abstract

Kimura's disease (KD) is a rare chronic disease with unknown origin. It remains controversial in KD's diagnosis, treatment, transformation and need further research. The aim of this study is to investigate the clinicopathologic features of KD and the relationship between the expression of Notch-1, Ki-67 receptor and the recurrence of KD. The hematoxylin and eosin sections and clinical data of 40 patients diagnosed with KD were examined retrospectively. Specimens were available in these 40 cases. Notch-1 and Ki-67 expression were examined using IHC (immunohistochemistry staining) analysis. Of 40 cases of KD (average age, 38.4 years; median age, 36.0 years), 34 cases (85.0%) were clinically seen to involve swelling of the head and neck region. Notch-1 and Ki-67 have a high expression in recurrent patients. High expression of Notch-1 receptor and Ki-67 tended to be found in patients who relapsed. This is the first study to discuss the correlation among Notch-1, Ki-67 and recurrent KD. These results suggest both of the markers may act as promising predictors for the recurrence and prognosis of KD. However, Notch-1 immunoexpression had no statistically significant association with the Ki-67 proliferation index.

Keywords: Ki-67 proliferation index; Kimura’s disease (KD); Notch-1 receptor; recurrence.

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Figures

Figure 1
Figure 1
Immunohistochemical staining of Notch-1 and Ki-67 expression in Kimura’s disease. A. Hematoxylin and eosin staining in KD (X200); B. Low expression of Ki-67 in KD (X200); C. High expression of Ki-67 in KD (X200); D. Negative expression of Notch-1 in KD (X200); E. Low expression of Notch-1 in KD (X200); F. High expression of Notch-1 in KD (X200).
Figure 2
Figure 2
Kaplan-Meier estimates of disease-free survival (DFS) with respect to Notch-1 and Ki-67 expression in 40 KD patients. A. DFS curves stratified by Notch-1 expression in KD tissues. B. DFS curves stratified by Ki-67 expression in KD tissues.
Figure 3
Figure 3
Kaplan-Meier estimates of disease-free survival (DFS) with respect to other parameters. A. DFS curves stratified by peripheral eosinophilia (%) in KD tissues. B. DFS curves stratified by largest mass sizes in KD tissues. C. DFS curves stratified by gender in KD tissues. D. DFS curves stratified by age in KD tissues. E. DFS curves stratified by multiplicity in KD tissues. F. DFS curves stratified by laterality in KD tissues.
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