Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Apr 15;7(5):2484-9.
eCollection 2014.

Synchronous pleural and peritoneal malignant mesothelioma: a case report and review of literature

Alessandro Del Gobbo  1 , Stefano Fiori  1 , Gabriella Gaudioso  1 , Eleonora Bonaparte  1 , Silvia Tabano  2 , Alessandro Palleschi  3 , Silvano Bosari  2 , Stefano Ferrero  4
Affiliations
Review

Synchronous pleural and peritoneal malignant mesothelioma: a case report and review of literature

Alessandro Del Gobbo et al. Int J Clin Exp Pathol. .

Abstract

The coexistence of mesothelioma and other primary malignancies has been previously reported in literature, but the finding of a pleural mesothelioma with a synchronous peritoneal mesothelioma has not been reported so far. We report a case of a 58-years-old woman that came to our attention for the incidental finding of an inguinal mass. Fine-needle biopsies of the mass and a thoracoscopy with pleural biopsies were performed, after imaging studies showed pleural thickenings suspicious for malignancy. Histological morphology and growth pattern were similar in both cases. Both tumors stained for calretinin, but only the pleural mesothelioma showed positivity for Wilms-Tumor 1 antibody. We tried to demonstrate with molecular biology techniques whether they were synchronous or one was the metastasis of the other, but our studies did not give informative results. The prognosis in this case is poor, and after 6 months the patient is still following a chemotherapy regimen, which is the only practicable approach given the extent of the disease.

Keywords: EGFR; Mesothelioma; X-chromosome inactivation; peritoneal malignancy; pleural malignancy.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Pleural mesothelioma, showing papillary and solid growth pattern with soft tissue infiltration (A: H&E, ×40; B: H&E, ×100). Calretinin (C: ×400) and WT1 (D: ×400) stained the whole tumor.
Figure 2
Figure 2
Peritoneal mesothelioma, also showing papillary and solid growth pattern with soft tissue infiltration (A: H&E, ×40; B: H&E, ×100). Immunohistochemistry for Calretinin (C: ×400) showed a strong positivity, but WT-1 (D: ×400) did not stain any tumoral cell.
Figure 3
Figure 3
Allelic profile of PBL (top), pleural (middle) and peritoneal (bottom) with the corresponding allele sizing are depicted.
See this image and copyright information in PMC

References

    1. Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Lyon: IARC Press; 2004. Chapter 2: Tumors of the pleura; pp. 25–144.
    1. Churg A, Cagle PT, Roggli VL. Tumors of the serosal membranes, 4th series. American Registry of Pathology. 2006. Diffuse malignant tumors of the serosal membranes; pp. 33–72.
    1. Allen TC, Moran C. Synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma. Arch Pathol Lab Med. 2006;130:721–724. - PubMed
    1. Raju B, Kotilingam K, Ravindra Babu G, Ramakoteswarao N. Pleural mesothelioma with inguinal lymphnode metastasis - a case report. Lung India. 1989;1:44–47.
    1. Attanoos RL, Thomas DH, Gibbs AR. Synchronous diffuse malignant mesothelioma and carcinomas in asbestos-exposed individuals. Histopathology. 2003;43:387–392. - PubMed

MeSH terms

Substances