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Review
. 2014 Apr 15;7(5):2654-7.
eCollection 2014.

Malignant myoepithelioma of the breast: a case report and review of literature

Yan-Fang Liang  1 , Jin-Cheng Zeng  2 , Jian-Bo Ruan  1 , Dong-Ping Kang  1 , Ling-Mei Wang  1 , Can Chen  1 , Jun-Fa Xu  2 , Qiu-Liang Wu  3
Affiliations
Review

Malignant myoepithelioma of the breast: a case report and review of literature

Yan-Fang Liang et al. Int J Clin Exp Pathol. .

Abstract

In this article, we described a malignant myoepithelioma of the breast (MMB) in a 69-year-old woman. Breast cancer derived from myoepithelial cells is very rare, usually benign. The diagnosis of MMB based on histological and immunohistochemical finding. In this case, the author diagnosed the tumor as MMB, because tumor tissues were immunopositive for 34βE12, P63, SMA, S-100, CD10, E-Cad and Ki-67, and immunnegative for CK5/6, desmin, ER, PR and C-erbB-2, because tumor tissue showed invasive growth and local hemorrhage or necrosis, suggesting malignant, and also because there was a transition between the tumor cells and hyperplastic myoepithelium of non-tumorous ducts. The patient's postoperative recovery is smooth and regular following of patient is essential.

Keywords: Malignant myoepithelioma; breast; immunohistochemistry.

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Figures

Figure 1
Figure 1
The MMB tissues were stained with hematoxylin and eosin. A: A nipple with spindle breast skin from patients after surgical operation. B: A 6 cm × 4 cm × 3 cm gray, hard quality and no envelope hard mass can clearly be seen at 1.5 cm from the bottom of the nipple. C: Tumor tissues display diffuse and irregular surrounding the breast duct or arrangement among the tubes, beam or nested shaped (40 ×). D: Hyaline cells and spindle cells were the two main cells in tumor tissues (200 ×).
Figure 2
Figure 2
MMB tissues were stained with immunohistochemistry. The tissues were immunopositive for 34βE12 (A), P63 (B), SMA (C), S-100 (D), CD10 (E), E-Cad (F) and Ki-67 (G) (A-G), and negative for CK5/6 (H), desmin (I), ER (J), PR (K), and C-erbB-2 (L) (H-L). (100 ×).
See this image and copyright information in PMC

References

    1. Liao KC, Lee WY, Chen MJ. Myoepithelial Carcinoma: A Rare Neoplasm of the Breast. Breast Care (Basel) 2010;5:246–249. - PMC - PubMed
    1. Noronha V, Cooper DL, Higgins SA, Murren JR, Kluger HM. Metastatic myoepithelial carcinoma of the vulva treated with carboplatin and paclitaxel. Lancet Oncol. 2006;7:270–1. - PubMed
    1. Endo Y, Sugiura H, Yamashita H, Takahashi S, Yoshimoto N, Iwasa M, Asano T, Toyama T. Myoepithelial carcinoma of the breast treated with surgery and chemotherapy. Case Rep Oncol Med. 2013;2013:164761. - PMC - PubMed
    1. Kuwabara H, Uda H. Clear cell mammary malignant myoepithelioma with abundant glycogens. J Clin Pathol. 1997;50:700–2. - PMC - PubMed
    1. Ohtake H, Iwaba A, Kato T, Ohe R, Maeda K, Matsuda M, Izuru K, Morimoto K, Katagiri S, Yamakawa M. Myoepithelial carcinoma of the breast with focal rhabdoid features. Breast J. 2013;19:100–3. - PubMed

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