Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2014 Apr 15;7(5):2701-6.
eCollection 2014.

Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp

Mitsuaki Ishida  1 , Muneo Iwai  1 , Akiko Kagotani  1 , Nozomi Iwamoto  1 , Hidetoshi Okabe  1
Affiliations
Case Reports

Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp

Mitsuaki Ishida et al. Int J Clin Exp Pathol. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Histopathological and immunohistochemical features of the lung tumor. A: The tumor is comprised of adenocarcinoma (right) and large cell neuroendocrine carcinoma (left) components. HE, x 40. B: The adenocarcinoma component is composed of cribriform glands consisting of atypical glandular cells containing large round to oval nuclei. HE, x 200. C: The large cell neuroendocrine carcinoma component is comprised of variably-sized nests with or without central necrosis. HE, x 100. D: Tumor cells of the large cell neuroendocrine carcinoma have relatively rich eosinophilic cytoplasm and large nuclei. Rosette formation is noted (inset). HE, x 400. E: Synaptophysin is expressed in the large cell neuroendocrine carcinoma component. x 200.
Figure 2
Figure 2
Histopathological and immunohistochemical features of the scalp nodule. A: Proliferation of variably-sized epithelial nests in the subcutis around the hair follicle. HE, x 100. B: The tumor cells have relatively rich eosinophilic cytoplasm and large round to oval nuclei. HE, x 400. C: Synaptophysin is expressed. x 400.
See this image and copyright information in PMC

References

    1. Brambilla E, Pugatch B, Geisinger K, Gal A, Sheppard MN, Guinee DG, Jiang SX, Lantuejoul S, Chang YL, Petersen I, Meyerson M, Hanash SM, Noguchi M. Large cell carcinoma. In: Travis WD, Bramblilla E, Muller-Hermelink HK, Harris CC, editors. World Health Organization Classification of Tumours.Pathology and Genetics of Tumours of the Lung, Pleura, Thymus, and Heart. Lyon: IARC Press; 2004. pp. 45–50.
    1. Isaka M, Nakagawa K, Ohde Y, Okumura T, Watanabe R, Ito I, Nakajima T, Kondo H. A clinicopathological study of peripheral, small-sized high-grade neuroendocrine tumours of the lung: differences between small-cell lung carcinoma and large-cell neuroendocrine carcinoma. Eur J Cardiothorac Surg. 2012;41:841–846. - PubMed
    1. Krathen RA, Orengo IF, Rosen T. Cutaneous metastasis: a meta-analysis of data. South Med J. 2003;96:164–167. - PubMed
    1. Hu SCS, Chen GS, Wu CS, Chai CY, Chen WT, Lan CCE. Rates of cutaneous metastases from different internal malignancies: experience from a Taiwanese medical center. J Am Acad Dermatol. 2009;60:379–387. - PubMed
    1. Lookingbill DP, Spangler N, Helm KF. Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol. 1993;29:228–236. - PubMed

MeSH terms

Substances

LinkOut - more resources