Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2015 Jan;174(1):49-54.
doi: 10.1007/s00431-014-2364-9. Epub 2014 Jun 27.

Metabolic acidosis in the first 14 days of life in infants of gestation less than 26 weeks

David Bourchier  1 , Philip John Weston
Affiliations
Observational Study

Metabolic acidosis in the first 14 days of life in infants of gestation less than 26 weeks

David Bourchier et al. Eur J Pediatr. 2015 Jan.

Abstract

Extremely immature newborns develop a self-limiting normal anion gap metabolic acidosis in early life. This study examined the natural history of this acidosis in a population of infants of gestation less than 26 weeks in the first 14 days of life. The acidosis was maximal on day 4 with a mean base deficit of 10.6 mmol/l and had resolved in 90 % of infants by day 11. Dopamine usage was the only independent predictor of the acidosis. Its use was associated with a greater degree of acidosis.

Conclusion: Extremely preterm infants experience a self-limiting normal anion gap metabolic acidosis in the first 2 weeks of life which is consistent with renal tubular immaturity.

PubMed Disclaimer

Comment in

References

    1. Eur J Pediatr. 2005 Mar;164(3):141-5 - PubMed
    1. J Hosp Med. 2010 Apr;5(4):E1-7 - PubMed
    1. J Pediatr. 1999 Dec;135(6):751-5 - PubMed
    1. J Pediatr. 2013 May;162(5):958-63.e1 - PubMed
    1. Pediatrics. 1995 Feb;95(2):238-43 - PubMed

Publication types

LinkOut - more resources