Radiogenomics: radiobiology enters the era of big data and team science

Barry S Rosenstein¹, Catharine M West², Søren M Bentzen³, Jan Alsner⁴, Christian Nicolaj Andreassen⁴, David Azria⁵, Gillian C Barnett⁶, Michael Baumann⁷, Neil Burnet⁸, Jenny Chang-Claude⁹, Eric Y Chuang¹⁰, Charlotte E Coles¹¹, Andre Dekker¹², Kim De Ruyck¹³, Dirk De Ruysscher¹⁴, Karen Drumea¹⁵, Alison M Dunning¹⁶, Douglas Easton¹⁷, Rosalind Eeles¹⁸, Laura Fachal¹⁹, Sara Gutiérrez-Enríquez²⁰, Karin Haustermans¹⁴, Luis Alberto Henríquez-Hernández²¹, Takashi Imai²², George D D Jones²³, Sarah L Kerns²⁴, Zhongxing Liao²⁵, Kenan Onel²⁶, Harry Ostrer²⁷, Matthew Parliament²⁸, Paul D P Pharoah²⁹, Timothy R Rebbeck³⁰, Christopher J Talbot³¹, Hubert Thierens¹³, Ana Vega¹⁹, John S Witte³², Philip Wong³³, Frederic Zenhausern³⁴; Radiogenomics Consortium

Affiliations

¹ Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York; Departments of Genetics and Genomic Sciences, Dermatology, and Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Radiation Oncology, New York University School of Medicine, New York, New York. Electronic address: barry.rosenstein@mssm.edu.
² Translational Radiobiology Group, Institute of Cancer Sciences, The University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, UK.
³ Division of Biostatistics and Bioinformatics, University of Maryland Greenebaum Cancer Center, and Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
⁴ Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.
⁵ Department of Radiation Oncology, Institute of Cancer of Montpellier (INSERM), Center for Cancer Research, Montpellier, France.
⁶ Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
⁷ Department of Radiation Oncology and OncoRay National Center for Radiation Research in Oncology, Technische Universität Dresden, and Helmholtz-Zentrum Dresden-Rossendorf Dresden, Germany.
⁸ University of Cambridge Department of Oncology, Cambridge Biomedical Campus, Addenbrooke's Hospital, Cambridge, UK.
⁹ Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁰ Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
¹¹ Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
¹² Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.
¹³ Department of Basic Medical Sciences, Ghent University, Ghent, Belgium.
¹⁴ Radiation Oncology, University Hospitals Leuven, and Department of Oncology, KU Leuven, Belgium.
¹⁵ Department of Oncology, Rambam Health Care Campus, Haifa, Israel.
¹⁶ Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
¹⁷ Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge, UK.
¹⁸ Division of Cancer Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK.
¹⁹ Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica-USC, CIBERER, IDIS, Santiago de Compostela, Spain.
²⁰ Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain.
²¹ Department of Radiation Oncology, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain.
²² Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan.
²³ Department Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.
²⁴ Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York.
²⁵ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
²⁶ Department of Pediatrics, The University of Chicago, Chicago, Illinois.
²⁷ Departments of Pathology, Genetics and Pediatrics, Albert Einstein College of Medicine at Yeshiva University, New York, New York.
²⁸ Department of Radiation Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
²⁹ Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
³⁰ Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
³¹ Department of Genetics, University of Leicester, Leicester, UK.
³² Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, California.
³³ Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
³⁴ Department of Basic Medical Sciences, Center for Applied Nanobioscience and Medicine, College of Medicine Phoenix, University of Arizona, Phoenix, Arizona.

PMID: 24969789
PMCID: PMC5119272
DOI: 10.1016/j.ijrobp.2014.03.009

Editorial

Radiogenomics: radiobiology enters the era of big data and team science

Barry S Rosenstein et al. Int J Radiat Oncol Biol Phys. 2014.

. 2014 Jul 15;89(4):709-13.

doi: 10.1016/j.ijrobp.2014.03.009.

Authors

Affiliations

¹ Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York; Departments of Genetics and Genomic Sciences, Dermatology, and Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Radiation Oncology, New York University School of Medicine, New York, New York. Electronic address: barry.rosenstein@mssm.edu.
² Translational Radiobiology Group, Institute of Cancer Sciences, The University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, UK.
³ Division of Biostatistics and Bioinformatics, University of Maryland Greenebaum Cancer Center, and Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
⁴ Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.
⁵ Department of Radiation Oncology, Institute of Cancer of Montpellier (INSERM), Center for Cancer Research, Montpellier, France.
⁶ Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
⁷ Department of Radiation Oncology and OncoRay National Center for Radiation Research in Oncology, Technische Universität Dresden, and Helmholtz-Zentrum Dresden-Rossendorf Dresden, Germany.
⁸ University of Cambridge Department of Oncology, Cambridge Biomedical Campus, Addenbrooke's Hospital, Cambridge, UK.
⁹ Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁰ Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
¹¹ Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
¹² Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.
¹³ Department of Basic Medical Sciences, Ghent University, Ghent, Belgium.
¹⁴ Radiation Oncology, University Hospitals Leuven, and Department of Oncology, KU Leuven, Belgium.
¹⁵ Department of Oncology, Rambam Health Care Campus, Haifa, Israel.
¹⁶ Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
¹⁷ Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge, UK.
¹⁸ Division of Cancer Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK.
¹⁹ Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica-USC, CIBERER, IDIS, Santiago de Compostela, Spain.
²⁰ Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain.
²¹ Department of Radiation Oncology, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain.
²² Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan.
²³ Department Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.
²⁴ Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York.
²⁵ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
²⁶ Department of Pediatrics, The University of Chicago, Chicago, Illinois.
²⁷ Departments of Pathology, Genetics and Pediatrics, Albert Einstein College of Medicine at Yeshiva University, New York, New York.
²⁸ Department of Radiation Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
²⁹ Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
³⁰ Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
³¹ Department of Genetics, University of Leicester, Leicester, UK.
³² Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, California.
³³ Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
³⁴ Department of Basic Medical Sciences, Center for Applied Nanobioscience and Medicine, College of Medicine Phoenix, University of Arizona, Phoenix, Arizona.

PMID: 24969789
PMCID: PMC5119272
DOI: 10.1016/j.ijrobp.2014.03.009

No abstract available

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Conflict of interest statement

E.Y. Chuang holds a patent on biomarkers for predicting response of esophageal cancer patients to chemoradiation therapy. The authors report no other conflict of interest.

References

1. West C, Rosenstein BS, Alsner J, et al. Establishment of a radiogenomics consortium. Int J Radiat Oncol Biol Phys. 2010;76:1295–1296. - PubMed
1. [Accessed February 1, 2014];Radiogenomics Consortium (RGC): Epidemiology and genomics research in NCI's Division of Cancer Control and Population Sciences. Available at http://epi.grants.cancer.gov/radiogenomics. Updated 2014.
1. Kerns SL, Ostrer H, Rosenstein BS. Radiogenomics: Using genetics to identify cancer patients at risk for development of adverse effects following radiotherapy. Cancer Discov. 2014;4:155–165. - PMC - PubMed
1. Barnett GC, Coles CE, Elliott RM, et al. Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: A prospective analysis study. Lancet Oncol. 2012;13:65–77. - PubMed
1. Genetic Associations and Mechanisms in Oncology (GAME-ON) [Accessed February 1, 2014];A network of consortia for post-genome wide association (post-GWA) research. Available at http://epi.grants.cancer.gov/gameon/. Updated 2014.

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Radiogenomics: radiobiology enters the era of big data and team science

Affiliations

Radiogenomics: radiobiology enters the era of big data and team science

Authors

Affiliations

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources