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. 1989 Jan 24;160(1):179-82.
doi: 10.1016/0014-2999(89)90670-5.

Potent contractile effect of endothelin in isolated guinea-pig airways

C A Maggi  1 , R Patacchini, S Giuliani, A Meli
Affiliations

Potent contractile effect of endothelin in isolated guinea-pig airways

C A Maggi et al. Eur J Pharmacol. .

Abstract

Endothelin produced a concentration-dependent (1 nM-0.3 microM) contraction of isolated guinea-pig airways (trachea and main bronchi). The response was unaffected by tetrodotoxin (1 microM) and slightly depressed by indomethacin (5 microM) but promptly abolished by isoprenaline (1 microM) or EDTA (3 mM). In the bronchi, the response to endothelin was enhanced by removal (rubbing) of the epithelium. The response of the trachea or bronchi to endothelin (0.3 microM) was unaffected by NiCl2 (0.1 mM) or omega conotoxin (0.1 microM) but was partially inhibited by nifedipine (1 microM).

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